诱导痰技术在慢性阻塞性肺疾病诊治中应用的研究进展  

Research progress of induced sputum technology in the diagnosis and treatment of chronic obstructive pulmonary disease

作　　者：史秀枝 刘杰[1] 曹晓红[2] SHI Xiuzhi;LIU Jie;CAO Xiaohong(Shanxi Medical University,Taiyuan 030000,China;Department of geriatric medicine,Fenyang hospital Affiliated to Shanxi Medical University,Fenyang 032200,China)

机构地区：[1]山西医科大学,太原030000 [2]山西医科大学附属汾阳医院老年医学科,山西汾阳032200

出　　处：《老年医学研究》2021年第1期57-60,共4页Geriatrics Research

摘　　要：慢性阻塞性肺疾病(COPD)是一种包括慢性支气管炎及肺气肿的慢性气道非特异性炎症。诱导痰技术是一种无创性气道采样方法,通过超声雾化吸入高渗盐水诱导痰液生成,从而进一步分析其中的细胞成分和上清液中的可溶性介质,以评估呼吸道炎症的性质和严重程度。近年来,诱导痰技术越来越多地应用于无痰、少痰的COPD患者中,可用于评估患者的气道炎症及气流阻塞严重程度、指导激素的使用、评估疗效及预后、区分COPD表型等。Chronic obstructive pulmonary disease(COPD)is a chronic airway nonspecific inflammation that includes chronic bronchitis and emphysema.The induction sputum technique is a noninvasive airway sampling method that induces sputum production by inhaling hypertonic saline through ultrasonic nebulization,resulting in further analysis of the cellular components therein and soluble mediators in the supernatant to assess the nature and severity of respiratory inflammation.Recently,the technique of induced sputum has been increasingly used in COPD patients with no sputum and lesss spu⁃tum,which can be used to assess airway inflammation and severity of airflow obstruction,guide the use of hormones,eval⁃uate efficacy and prognosis,and distinguish COPD phenotypes.

关 键 词：诱导痰技术 慢性阻塞性肺疾病 炎症 

分 类 号：R563.9[医药卫生—呼吸系统] R446.1[医药卫生—内科学]