老年人群心脑血管动脉钙化与骨密度减低的关系研究  

Study on the relationship between cardiovascular and cerebrovascular artery calcification and bone mineral density reduction in the elderly

作　　者：洪文娟 周锐 刘冬 黄洁 马晶晶 王从过 符晓艳 周华东 HONG Wenjuan;ZHOU Rui;LIU Dong;HUANG Jie;MA Jingjing;WANG Congguo;FU Xiaoyan;ZHOU Huadong(Bengbu Medical College,Bengbu,Anhui 233000,China;Department of Orthopedics,Southwest Hospital of Army Medical University,Chongqing 400042,China;Department of Trauma surgery,Army Characteristic Medical Center,Chongqing 400042,China;Department of Neurology,Army Characteristic Medical Center,Chongqing 400042,China)

机构地区：[1]蚌埠医学院,安徽蚌埠233000 [2]陆军军医大学西南医院骨科,重庆400042 [3]陆军特色医学中心创伤外科,重庆400042 [4]陆军特色医学中心神经内科,重庆400042

出　　处：《重庆医学》2021年第4期567-572,共6页Chongqing medicine

基　　金：国家自然科学基金项目(81972112);重庆市技术创新与应用发展专项面上项目(cstc2019jscx-msxmX0254)。

摘　　要：目的探讨老年人群心脑血管动脉钙化与骨密度减低的相关性。方法选取2016年1月至2017年12月神经内科收治的1566例老年患者为研究对象,根据CT血管成像(CTA)检查分为钙化斑块组和非钙化斑块组,比较两组一般资料,进行骨密度检测,同时采用logistic回归分析钙化斑块的危险因素及其与骨密度减低的相关性。结果在调整了混杂因素后,骨密度降低明显增加了心脑血管动脉钙化斑块的发生风险(P<0.05)。吸烟、高血压、糖尿病、血脂异常与动脉钙化斑块具有明显相关性(P<0.05)。在骨密度减低时,血清骨保护素(OPG)、骨钙素(OC)及Ⅰ型胶原交联末端肽(CTX)水平与动脉钙化斑块明显相关(P<0.05)。结论老年人群心脑血管动脉钙化与骨密度减低密切相关。Objective To investigate the relationship between cardiovascular and cerebrovascular artery calcification and bone mineral density reduction in the elderly.Methods A total of 1566 elderly patients admitted from January 2016 to December 2017 were selected.According to CT angiography(CTA)examination,they were divided into the calcified plaque group and the non-calcified plaque group.The general data of the two groups were compared.Bone mineral density detection was performed,and logistic regression was used to analyze the risk factors of calcified plaque and its correlation with bone density reduction.Results After adjusting for confounding factors,the decrease in bone density significantly increased the risk of calcified plaques in the cardiovascular and cerebrovascular arteries(P<0.05).Smoking,hypertension,diabetes,dyslipidemia and arterial calcified plaques were significantly correlated(P<0.05).When bone density decreases,the levels of serum osteoprotegerin(OPG),osteocalcin(OC)and type I collagen cross-linked terminal peptide(CTX)were significantly related to arterial calcified plaques(P<0.05).Conclusion Cardiovascular and cerebrovascular artery calcification is closely related to the decrease of bone mineral density.

关 键 词：血管钙化 斑块 动脉粥样硬化 颈动脉 冠状血管 骨密度 

分 类 号：R714.252[医药卫生—妇产科学]