开颅手术联合腰大池持续引流术对颅内动脉瘤患者认知功能的影响研究  

Study on the effect of craniotomy combined with continuous lumbar drainage on the cognitive function of patients with intracranial aneurysm

作　　者：张俊峰 钟诚 ZHANG Junfeng;ZHONG Cheng(The First Department of Surgery,Traditional Chinese Medicine Hospital of Yongchuan District,Chongqing 402160,China)

机构地区：[1]重庆市永川区中医院外一科,402160

出　　处：《重庆医学》2021年第4期663-666,共4页Chongqing medicine

摘　　要：目的探讨开颅手术联合腰大池持续引流术对颅内动脉瘤患者认知功能的影响。方法选取2016年6月至2018年7月该院行开颅手术联合腰大池持续引流术治疗的40例颅内动脉瘤患者作为研究对象(A组),同时选取2014年4月至2016年5月行开颅手术的颅内动脉瘤患者40例作为对照组(B组),比较两组认知功能、基质细胞衍生因子-1A(SDF-1A)、转化生长因子-β(TGF-β)。结果A、B组治疗有效率为85.00%、62.50%(P<0.05)。与术后1周比较,术后1、3、6个月两组简易智力状态检查(MMSE)评分升高,且A组MMSE评分高于B组(P<0.05)。治疗后两组SDF-1A、TGF-β水平均低于治疗前,且A组低于B组(P<0.05)。结论开颅手术联合腰大池持续引流术对颅内动脉瘤患者认知功能改善有较好效果。Objective To explore the effect of craniotomy combined with continuous lumbar drainage on the cognitive function of patients with intracranial aneurysm.Methods From June 2016 to July 2018,40 patients with intracranial aneurysm who underwent craniotomy combined with continuous lumbar cistern drainage were selected as the research object(group A),and the period from April 2014 to May 2016 was selected.Forty patients with intracranial aneurysm undergoing craniotomy were selected as the control group(group B),compared the cognitive function,stromal cell-derived factor-1A(SDF-1A)and transforming growth factor-β(TGF-β)between the two groups.Results The effective rates of treatment in groups A and B was 85.00%and 62.50%,respectively(P<0.05).Compared with 1 week after operation,mini-mental state examination(MMSE)scores of the two groups increased at 1,3,and 6 months after operation,and the MMSE score of group A was higher than that of group B(P<0.05).After treatment,the levels of SDF-1A and TGF-βin the two groups were lower than before treatment,and group A was lower than group B(P<0.05).Conclusion Craniotomy combined with continuous drainage of lumbar cistern has a good effect on the improvement of cognitive function in patients with intracranial aneurysm.

关 键 词：神经外科手术 腰大池持续引流术 颅内动脉瘤 认知功能 趋化因子CXCL12 转化生长因子Β 

分 类 号：R651[医药卫生—外科学]