阻塞性睡眠呼吸暂停低通气综合征导致心血管疾病相关机制  

Research progress on the related mechanism of obstructive sleep apnea hypopnea syndrome and cardiovascular disease

作　　者：冯葶 郭子宏 FENG Ting;GUO Zihong(Department of cardiology, The Second Affiliated Hospital of Kunming Medical University, Kunming 650101;Hypertension Ward, Fuwai Cardiovascular Hospital, Kunming 650000,China.)

机构地区：[1]昆明医科大学第二附属医院心内科,650101 [2]云南阜外心血管病医院高血压病区,650000

出　　处：《中国老年保健医学》2021年第1期101-105,共5页Chinese Journal of Geriatric Care

摘　　要：阻塞性睡眠呼吸暂停低通气综合征的发病率逐年增加,人们逐渐认识到阻塞性睡眠呼吸暂停低通气综合征是一种会引起全身多系统损伤的疾病。大量研究证实阻塞性睡眠呼吸暂停低通气综合征与包括高血压、冠心病、心律失常、心力衰竭等在内的心血管疾病之间具有显著相关性。本文针对胸腔负压改变、自主神经紊乱、氧化应激及炎症反应、细胞凋亡等阻塞性睡眠呼吸暂停低通气综合征的发生发展机制及其与心血管疾病相关联的证据展开讨论,阐述两者之间潜在的因果关系,为临床诊治提供新的理论依据。The incidence of obstructive sleep apnea hypopnea syndrome is increasing year by year,and people gradually realize that obstructive sleep apnea hypopnea syndrome is a disease that can cause multiple system damages throughout the body.A large number of studies have confirmed that obstructive sleep apnea hypopnea syndrome has a significant correlation with cardiovascular diseases including hypertension,coronary heart disease,arrhythmia,heart failure,etc.This article will discuss the mechanism of occurrence and development of obstructive sleep apnea hypopnea syndrome such as changes in thoracic negative pressure,autonomic nervous disorders,oxidative stress and inflammation,cell apoptosis and the evidence related to cardiovascular disease,The potential causal relationship between the two provides a new theoretical basis for clinical diagnosis and treatment.

关 键 词：阻塞性睡眠呼吸暂停低通气综合征 心血管疾病 呼吸暂停低通气指数 慢性间歇性缺氧 持续气道内正压通气 

分 类 号：R766[医药卫生—耳鼻咽喉科] R54[医药卫生—临床医学]