自噬在蒽环类药物引起的心脏毒性中的作用的研究进展  

Research progress of autophagy in anthracycline induced cardiotoxicity

作　　者：胡涛 HUMAYOUN Amini 李媛[1] 吴洋 郭宇轩 夏珂[1] HU Tao;HUMAYOUN Amini;LI Yuan;WU Yang;GUO Yuxuan;XIA Ke(Department of Cardiology,Xiangya Hospital of Central South University,Changsha,Hunan 410008,China)

机构地区：[1]中南大学湘雅医院心血管内科,湖南省长沙市410008

出　　处：《中国动脉硬化杂志》2021年第2期166-170,共5页Chinese Journal of Arteriosclerosis

基　　金：湖南省自然科学基金项目(2016JJ6166)。

摘　　要：在临床中,化疗相关的心脏毒性越来越受到关注,这常常阻碍癌症的最佳治疗。蒽环类药物(AC)是最常用的抗癌药物,它对血液系统恶性肿瘤非常有效。现代成像技术虽可识别出有AC引起的心脏毒性(AIC)风险的患者,但在治疗上效果欠佳,部分原因是AIC的分子机制仍不完全清楚。虽然AIC最初被归因于细胞氧化应激所触发,但抗氧化剂不能预防AIC,提示AIC涉及其他机制。一系列研究表明,自噬可能扮演了重要的作用。本综述将总结自噬在AIC中作用的相关证据,以探寻靶向心脏自噬预防AIC的作用。In clinical practice, more and more attention has been paid to chemotherapy-related cardiotoxicity, which often hinders the optimal treatment of cancer. Anthracyclines(AC) are the most commonly used anticancer drug, which are very effective for hematological malignancies. Although modern imaging techniques can identify patients at risk of AC induced cardiotoxicity(AIC), the therapeutic effect is not good, part of the reason is that the molecular mechanism of AIC is still unclear. Although AIC is initially attributed to cellular oxidative stress, antioxidants do not prevent AIC, suggesting that AIC involves other mechanisms. A series of studies have shown that autophagy may play an important role. This review will summarize the relevant evidence of autophagy in AIC to explore the role of targeted cardiac autophagy in the prevention of AIC.

关 键 词：蒽环类药物 心脏毒性 自噬 

分 类 号：R54[医药卫生—心血管疾病]