血细胞参数预测冠状动脉支架内再狭窄的研究进展  

Advances in the prediction of coronary in-stent restenosis by blood cell parameters

作　　者：姜南[1,2] 谷广明 谢勇 JIANG Nan;GU Guangming;XIE Yong(Dalian Medical University,Dalian,Liaoning 116000,China;Department of Cardiovascular Medcine,Northern Jiangsu People's Hospital,Yangzhou,Jiangsu 225000,China;Department of Cardiovascular Medcine,Henan Provincial People's Hospital,Zhengzhou,Henan 450003,China)

机构地区：[1]大连医科大学,辽宁省大连市116000 [2]江苏省苏北人民医院心血管内科,江苏省扬州市225000 [3]河南省人民医院心血管内科,河南省郑州市450003

出　　处：《中国动脉硬化杂志》2021年第2期179-184,共6页Chinese Journal of Arteriosclerosis

摘　　要：冠状动脉介入技术的日益成熟和新型药物洗脱支架(DES)的广泛使用极大降低了支架内再狭窄(ISR)的风险。然而,ISR仍然是冠状动脉介入治疗失败的重要原因。炎症和血小板活化是ISR病理生理学的重要过程。与之相关的血细胞参数,包括细胞计数和形态参数,是临床实践中炎症反应和血小板活化的有用标志物。近年来大量临床研究强调了血细胞参数独立预测DES术后ISR发生风险的价值。比如中性粒细胞/淋巴细胞比值作为一种炎症指标,被认为是ISR及动脉粥样硬化斑块不稳定性发生的风险预测因子。平均血小板体积作为被广泛应用的血小板活化参数,已被证明是ISR发生风险和抗血小板药物疗效的预测因子。血小板/淋巴细胞比率、红细胞分布宽度和血小板分布宽度等指标也与ISR的发生存在一定的相关性。因此文章对这些参数进行综述,以期对冠状动脉ISR的风险提供新的预测指标。The growing development of coronary intervention and the widespread use of drug-eluting stents(DES) have greatly reduced the risk of in-stent restenosis(ISR). However, ISR is still an important clinical challenge of coronary intervention. Inflammation and platelet activation are important processes in pathophysiology of ISR. Related hemocyte parameters, including cell count and morphological parameters, are useful markers of inflammatory response and platelet activation in clinical practice. In recent years, a large number of clinical studies have emphasized the value of blood cell parameters independently predicting the risk of ISR after DES. For example, the neutrophil/lymphocyte ratio as an indicator of inflammation is considered to be a predictor of ISR and atherosclerotic plaque instability. As a widely used platelet activation parameter, mean platelet volume has been shown to be a predictor of ISR risk and antiplatelet efficacy. Studies have shown that markers such as platelet/lymphocyte ratio, red blood cell distribution width and platelet distribution width are also correlated with the occurrence of ISR. Therefore, these parameters were reviewed in order to provide new predictors of ISR risk in coronary arteries.

关 键 词：血细胞参数 冠心病 药物洗脱支架 支架内再狭窄 

分 类 号：R5[医药卫生—内科学]