矿物药治疗精神分裂症的用药规律探析  

Study on Rule of Mineral Drugs in the Treatment of Schizophrenia

作　　者：庄红艳[1,2] 冯秀杰 刘杰[1,2] 宁艳哲 赵爽[1,2] 李雪[1,2] 薛春苗 ZHUANG Hongyan;FENG Xiujie;LIU Jie;NING Yanzhe;ZHAO Shuang;LI Xue;XUE Chunmiao(Dept.of Pharmacy,Beijing Anding Hospital,Capital Medical University,the National Clinical Research Center for Mental Disorders&Beijing Key Laboratory of Mental Disorders,Beijing 100088,China;Capital Medical University,Advanced Innovation Center for Human Brain Protection,Beijing 100069,China;Dept.of Pharmacy,Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China)

机构地区：[1]首都医科大学附属北京安定医院药事部,国家精神心理疾病临床医学研究中心,精神疾病诊断与治疗北京市重点实验室,北京100088 [2]首都医科大学,人脑保护高精尖创新中心,北京100069 [3]北京中医药大学东直门医院药学部,北京100700

出　　处：《中国医院用药评价与分析》2021年第1期90-92,96,共4页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：国家自然科学基金(No.81873398);首都卫生发展科研专项资助(No.首发2018-4-2124);首都卫生发展科研专项资助(No.首发2018-1-2122);北京市中医药科技发展资金项目资助(No.JJ2018-42);北京市医院管理中心“登峰”计划专项经费资助(No.DFL20191901);北京市属医院科研培育项目(No.PZ2020031)。

摘　　要：目的:挖掘矿物药治疗精神分裂症的用药规律,为临床治疗精神分裂症提供参考。方法:收集2018年1月至2020年8月首都医科大学附属北京安定医院(以下简称"我院")门诊治疗精神分裂症的中药饮片方剂,采用Excel 2010、SPSS 19.0软件对矿物药使用规律进行分析,分析治疗精神分裂症的矿物药用药频次,统计矿物药所属功效,并对药物性味加以归类,分析各矿物药归经特点。结果:共收集到我院门诊治疗精神分裂症的中药饮片方剂971首,组方药物共239味,其中矿物药12味。使用频次排序居前3位的矿物药分别为珍珠母、生石膏和生牡蛎;以功效分类,平肝息风类、安神类及清热类矿物药使用最多;药性方面,以性寒、平、大寒和微寒的矿物药居多;药味方面,以咸味、甘味和辛味的矿物药居多;归经方面,主要归肝经、心经、肾经、肺经和胃经。结论:临床治疗精神分裂症多以平肝息风类、安神类及清热类矿物药为法,常选用具有重镇安神、平肝潜阳和定惊明目功效的咸寒、甘寒之品。OBJECTIVE:To probe into the rule of mineral drugs in the treatment of schizophrenia,so as to provide reference for clinical treatment of schizophrenia.METHODS:Traditional Chinese medicine decoction pieces in the treatment of schizophrenia in Beijing Anding Hospital,Capital Medical University(hereinafter referred to as"our hospital")from Jan.2018 to Aug.2020 were collected.Excel 2010 and SPSS 19.0 softwares were used to analyze the rules and the frequency of mineral drugs in the treatment of schizophrenia,count the efficacy of mineral drugs,classify the properties and flavors,and summarize the characteristics of distribution of mineral drugs.RESULTS:A total of 971 pieces of traditional Chinese medicine prescriptions for the treatment of schizophrenia were collected in the outpatient department of our hospital,there were 239 traditional Chinese medicines in the prescription,of which 12 were mineral drugs.The top 3 mineral drugs ranked by frequency of use were respectively nacre mother of pearl,gypsum and raw oyster shell.Classified by efficacy,mineral drugs for calming the liver and nerves and clearing away heat were used frequently.In terms of medicinal properties,most of the mineral drugs were cold,peaceful,greatly cold and slightly cold.In terms of medicinal taste,most of the mineral drugs were salty,sweet and pungent.In terms of meridians,the main meridians were respectively liver,heart,kidney,lung and stomach.CONCLUSIONS:Clinical treatment of schizophrenia is mostly based on mineral drugs for calming liver and nerves and clearing away heat,and often choose salty cold and sweet cold drugs that have the effects of calming the nerves,suppressing hyperactive liver and subsiding yang and improving eyesight.

关 键 词：矿物药 精神分裂症 用药规律 中药饮片 数据挖掘 

分 类 号：R932[医药卫生—生药学]