P50和P200型Ex-PRESS青光眼引流钉治疗原发性开角型青光眼的疗效及安全性对比  

Comparison of the therapeutic efficacy and safety of P50 and P200 Ex-PRESS miniature glaucoma device implantation for primary open-angle glaucoma

作　　者：孙重 张莹[1] 吴作红 周和政 SUN Zhong;ZHANG Ying;WU Zuohong;ZHOU Hezheng(Aier Eye Hospital of Wuhan University,Wuhan 430060,Hubei Province,China)

机构地区：[1]武汉大学附属爱尔眼科医院,湖北省武汉市430060

出　　处：《眼科新进展》2021年第2期162-165,共4页Recent Advances in Ophthalmology

基　　金：武汉市临床医学(西医药类)科研项目(编号WX16Z02)。

摘　　要：目的对比P50型和P200型Ex-PRESS青光眼引流钉治疗原发性开角型青光眼(POAG)的疗效及安全性。方法选取2016年5月至2018年12月在武汉大学附属爱尔眼科医院住院的POAG患者32例(32眼)作为研究对象。采用随机数字表法将患者分为P50组和P200组,每组16例(16眼),分别行P50型和P200型Ex-PRESS青光眼引流钉植入术。术后随访12个月,观察各组眼压、最佳矫正视力、手术成功率、并发症发生情况。结果P50组和P200组患者术后1周、1个月、3个月、6个月、12个月眼压均低于术前,差异均有统计学意义(均为P<0.05);两组患者间术前及术后1周、1个月、3个月、6个月、12个月眼压相比,差异均无统计学意义(均为P>0.05)。术后12个月P50组和P200组患者最佳矫正视力分别为4.33±0.26、4.14±0.59,均较术前轻微下降,但差异均无统计学意义(均为P>0.05);术后12个月两组患者最佳矫正视力比较,差异亦无统计学意义(t=1.67,P>0.05)。术后1周、1个月、3个月两组患者手术完全成功率均为100.0%;术后6个月,P50组手术完全成功率为87.5%,P200组为93.8%,两组差异无统计学意义(χ^(2)=0.3677,P>0.05);术后12个月,P50组手术完全成功率为75.0%,P200组为87.5%,两组差异无统计学意义(χ^(2)=0.8205,P>0.05)。术后12个月,P50组出现滤过泡包裹8眼,P200组3眼,差异有统计学意义(P<0.05);其中,P50组4眼、P200组2眼通过针刺分离联合5-氟尿嘧啶注射后滤过道恢复通畅。结论P50型和P200型Ex-PRESS青光眼引流钉植入术均能有效治疗POAG,而P200型青光眼引流钉植入术后晚期滤过泡包裹发生率较低。Objective To compare the efficacy and safety of P50 and P200 Ex-PRESS miniature glaucoma device implantation for primary open-angle glaucoma(POAG).Methods Totally 32 eyes from 32 POAG patients were performed from May 2016 to December 2018 in Aier eye hospital of Wuhan university.The patients were randomized into 2 groups(P50 and P200)according to randomized digital table,16 patients in each group were implanted with either P50 or P200 Ex-PRESS miniature glaucoma device respectively.All patients were followed up for 12 months to compare the intraocular pressure,best corrected visual acuity,success rate and complications.Results In P50 group and P200 group,the postoperative intraocular pressure at 1 week,1 month,3 months,6 months and 12 months were lower than preoperative intraocular pressure,and the differences were statistically significant(all P<0.05).There was no statistically significant difference in intraocular pressure between the two groups at preoperation and 1 week,1 month,3 months,6 months and 12 months postoperation(all P>0.05).The average best corrected visual acuity of the two groups was 4.33±0.26 versus 4.14±0.59 at 12 months postoperation,with slight decrease,but there was no significant difference between preoperation and postoperation(P>0.05).There was no statistically significant difference in average best corrected visual acuity between the two groups at 12 months postoperation(t=1.67,P>0.05).In the two groups,complete success rate of the operation was 100.0%at 1 week,1 month and 3 months postoperation.Complete success rate of the operation was 87.5%in P50 group versus 93.8%in P200 group at 6 months postoperation,and the difference was no statistically significant(χ^(2)=0.3677,P>0.05).Complete success rate of the operation was 75.0%in P50 group versus 87.5%in P200 group at 12 months postoperation,and the difference was no statistically significant(χ^(2)=0.8205,P>0.05).Encapsulated bleb occurred in both groups at 12 months postoperation,and 8 eyes in P50 group and 3 eyes in P200 group,the di

关 键 词：Ex-PRESS青光眼引流钉植入术 原发性开角型青光眼 眼压 治疗效果 术后并发症 

分 类 号：R775[医药卫生—眼科]