补肺活血中药对间质性肺病患者血清KL-6、CXCL13及预后的影响  

Effect of Chinese medicines on serum KL-6,CXCL13 and prognosis in patients with interstitial lung disease

作　　者：田琳[1] 袁成波[1] 姜威 陈梦竹 刘玥 王檀[1] TIAN Lin;YUAN Chengbo;JIANG Wei;CHEN Mengzhu;LIU Yue;WANG Tan(Affiliated Hospital of Changchun University of Chinese Medicine,Changchun 130021,China;Shanghai Jiading District Anting Hospital,Shanghai 201805,China;Changchun University of Chinese Medicine,Changchun 130117,China)

机构地区：[1]长春中医药大学附属医院,长春130021 [2]上海市嘉定区安亭医院,上海201805 [3]长春中医药大学,长春130117

出　　处：《吉林中医药》2021年第1期78-81,共4页Jilin Journal of Chinese Medicine

基　　金：吉林省科技发展计划项目(20150204045YY)。

摘　　要：目的探究补肺活血中药治疗对间质性肺病患者血清涎液化糖链抗原-6(KL-6)、趋化因子配体13(CXCL13)及预后的影响。方法选取80例间质性肺病患者作为研究对象,经随机数字表法分为对照组和观察组,各40例。对照组采用常规西医药物(口服乙酰半胱氨酸泡腾片)治疗,观察组采用补肺活血中药治疗。比较2组临床疗效,血清KL-6和CXCL13水平,肺总量(TLC)、动脉血氧分压(PaO2)、血氧饱和度(SaO2)以及不良反应发生率。结果观察组治疗总有效率(95.00%,38/40)高于对照组(80.00%,32/40)(P<0.05)。观察组治疗后血清KL-6和CXCL13水平均低于治疗前和对照组(P<0.05)。观察组治疗后TLC、PaO2、SaO2水平均高于治疗前和对照组(P<0.05)。观察组不良反应发生率低于对照组(P<0.05)。结论补肺活血中药治疗间质性肺病疗效确切,可改善患者KL-6、CXCL13相关血清学标志物水平和血气分析指标,增强患者肺功能,安全性高。Objective To explore the effect of Chinese medicines for invigorating lung and promoting blood circulation on serum salivary liquefied sugar chain antigen-6 (KL-6),chemokine ligand 13 (CXCL13) and prognosis in patients with interstitial lung disease.Methods A total of 80 patients with interstitial lung disease,admitted to our hospital from January to December 2019,were selected as the research subjects,and they were divided into control group and observation group by random number table method,each with 40 cases.The control group was treated with conventional western medicine (oral acetylcysteine effervescent tablets),and the observation group was treated with Chinese medicines to invigorate lung and promote blood circulation.The clinical efficacy of the two groups was compared,including serum KL-6 and CXCL13 levels,total lung volume (TLC),partial arterial oxygen pressure (PaO2),blood oxygen saturation (SaO2) and the incidence of adverse reactions.Results The total effective rate in the observation group (95.00%,38/40) was higher than that in the control group (80.00%,32/40) (P<0.05).Serum KL-6 and CXCL13 levels in the observation group after treatment were lower than those before and in the control group (P<0.05).The levels of TLC,PaO2 and SaO2 in the observation group after treatment were higher than those before and in the control group (P<0.05).The incidence rate of adverse reactions in the observation group was 7.50%,lower than 25.00% in the control group (P<0.05).Conclusion The Chinese medicines for invigorating the lung and activating blood circulation has a definite effect in the treatment of interstitial lung disease.It can improve the level of serological markers and blood-qi analysis index as KL-6 and CXCL13,enhance the patients’ lung function,and having high safety.

关 键 词：间质性肺病 补肺活血中药 疗效 血清学标志物 预后 

分 类 号：R563[医药卫生—呼吸系统]