颈痛颗粒治疗神经根型颈椎病的研究进展  

Research progress of Cervical Pain Granules in the treatment of cervical radiculopathy

作　　者：方圣杰 朱立国[1] 魏戌[2] 孙凯 王旭 师彬[3] 杨少锋[4] FANG Shengjie;ZHU Liguo;WEI Xu;SUN Kai;WANG Xu;SHI Bin;YANG Shaofeng(The second Department of Spine,Wang Jing Hospital of CACMS,Beijing 100102,China;Office of Academic Research,Wang Jing Hospital of CACMS,Beijing 100102,China;Shandong Medicinal Biotechnology Center,Shandong Province,Ji’nan 250062,China;the First Department of Spine,the First Hospital of Hu’nan University of Chinese Medicine,Hu’nan Province,Changsha 410007,China)

机构地区：[1]中国中医科学院望京医院脊柱二科,北京100102 [2]中国中医科学院望京医院科研处,北京100102 [3]山东省医药生物技术研究中心,山东济南250062 [4]湖南中医药大学第一附属医院脊柱一科,湖南长沙410007

出　　处：《中国医药导报》2021年第3期48-51,共4页China Medical Herald

基　　金：国家中医药管理局中医药传承与创新“百千万”人才工程(岐黄工程)岐黄学者计划;中国中医科学院中央级公益性科研院所基本科研业务中医药循证能力提升建设项目(ZZ13-024-7);中国中医科学院基本科研业务“十三五”重点领域科研项目(ZZ10-022);中国中医科学院优秀青年科技人才(创新类)培养专项计划项目(ZZ13-YQ-039)。

摘　　要：神经根型颈椎病(CR)是骨科临床常见病与多发病,属于中医“痹证”范畴。CR发病机制较为复杂,尚没有统一的定论。近年来以颈痛颗粒为代表的中成药治疗CR在临床中应用广泛,颈痛颗粒临床与基础研究逐渐受到关注。颈痛颗粒单用与联用对于缓解CR临床症状与体征具有较好作用,然而基础研究开展较少,通过回顾现有研究发现颈痛颗粒治疗CR药效主要表现为抗炎、镇痛、活血化瘀的作用,本文基于现有文献,综述了颈痛颗粒治疗CR药效学和基础学研究现况,以期更好应用于临床治疗。但该方作用机制研究有限,未来针对该方的机制研究将深化对“活血化瘀、行气止痛”治法指导下治疗CR的认识,对临床进一步优化该治法下的组方用药具有重要意义,为药物研发与应用提供参考。Cervical spondylotic radiculopathy(CR)is a common and frequent orthopedic disease,which belongs to the category of Bi syndrome in traditional Chinese medicine.The pathogenesis of CR is relatively complex and there is no unified conclusion.In recent years,the Chinese patent medicine CR,represented by the Cervical Pain Granules,has been widely used in clinical practice,the clinical and basic research of Cervical Pain Granules has attracted more and more attention.The single and combined use of Cervical Pain Granules has a good effect on relieving the clinical symptoms and signs of CR,however,basic research is rare.Through reviewing the existing studies,it was found that the main effects of the treatment of CR were anti-inflammatory,analgesic and promoting blood circulation and removing stasis.Based on the existing literature,this paper reviews the current status of pharmacodynamics and basic science research on the treatment of CR by Cervical Pain Granules in order to better apply in clinical treatment.However,the research on the mechanism of action of this prescription is limited,and the future research on the mechanism of this prescription will deepen the understanding of CR treatment under the guidance of“promoting blood circulation and removing blood stasis,promoting qi and relieving pain”,it is of great significance to further optimize the prescription drugs under this treatment,and provide reference for drug development and application.

关 键 词：颈痛颗粒 中成药 神经根型颈椎病 研究进展 

分 类 号：R681[医药卫生—骨科学]