聚乳酸凝胶联合人工周期疗法在宫腔镜下宫腔粘连分离术后的应用效果  

Effect of Polylactic Acid Gel combined with artificial cycle therapy after hysteroscopy transcervical resection of adhesion

作　　者：夏智勇[1] 兰李[1] 冉伟[1] XIA Zhiyong;LAN Li;RAN Wei(Department of Obstetrics and Gynecology,Affiliated Hospital of North Sichuan Medical College,Sichuan Province,Nanchong 637000,China)

机构地区：[1]川北医学院附属医院妇产科,四川南充637000

出　　处：《中国医药导报》2021年第3期124-127,共4页China Medical Herald

摘　　要：目的探讨聚乳酸凝胶联合人工周期疗法在宫腔镜下宫腔粘连分离术(TCRA)术后的应用效果。方法回顾性分析2018年12月—2020年2月川北医学院附属医院接受TCRA的210例宫腔粘连(IUA)患者的诊疗情况。根据治疗方式将其分为实验组(108例)和对照组(102例),对照组在TCRA术后使用人工周期疗法治疗,实验组在对照组基础上,联合聚乳酸凝胶治疗。治疗3个周期后,比较两组宫腔形态、月经改善情况、再粘连发生率、宫腔容积、子宫内膜厚度的变化及不良反应。结果实验组宫腔形态、月经改善总有效率高于对照组,差异均有统计学意义(均P<0.05)。实验组再粘连发生率低于对照组,差异有统计学意义(P<0.05)。治疗后实验组宫腔容积大于对照组,子宫内膜厚度高于对照组,差异有统计学意义(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论宫腔镜下TCRA术后应用聚乳酸凝胶联合人工周期疗法效果显著,值得应用推广。Objective To study the application effect of Polylactic Acid Gel combined with artificial cycle therapy after hysteroscopic transcervical resection of adhesion(TCRA).Methods A total of 210 patients with intrauterine adhesions(IUA)who underwent TCRA in Affiliated Hospital of North Sichuan Medical College from December 2018 to February 2020 were retrospectively analyzed,according to treatment methods,they were divided into experimental group(108 cases)and control group(102 cases).Control group was treated with artificial cycle therapy after TCRA,and experimental group was treated with Polylactic Acid Gel on the basis of control group.After three cycles of treatment,the uterine cavity morphology,menstrual improvement and incidence of readhesion,uterine cavity volume and endometrial thickness,and adverse reactions were compared between two groups.Results The total effective rates of uterine cavity morphology and menstruation improvement in experimental group were higher than those in control group,with statistically significant(P<0.05).The incidence of readhesion in experimental group was lower than that in control group,with statistically significant(P<0.05).Uterine cavity volume in experimental group was bigger than that in control group and endometrial thickness in experimental group was higher than that in control group,with statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between two groups(P>0.05).Conclusion The efficacy of Polylactic Acid Gel combined with artificial cycle therapy after hysteroscopic TCRA is significant,which is worthy of application and promotion.

关 键 词：宫腔粘连 宫腔粘连分离术 聚乳酸凝胶 人工周期 宫腔形态 月经 不良反应 

分 类 号：R711.74[医药卫生—妇产科学]