地佐辛复合丙泊酚对无痛人流术不良反应的影响观察  

Effects of Dezocine combined with Propofol on adverse reactions of painless induced abortion

作　　者：王兰兰 叶海燕 阮加萍[1] 茆庆洪[1] 陈晏 Wang Lanlan;Ye Haiyan;Ruan Jiaping;Mao Qinghong;Chen Yan(Department of Anesthesiology,Affiliated Hospital of Integrated Traditional Chinese and Western Medicine,Nanjing University of Traditional Chinese Medicine,Nanjing,Jiangsu 210028,China;Department of Obstetrics and Gynecology,Affiliated Hospital of Integrated Traditional Chinese and Western Medicine,Nanjing University of Traditional Chinese Medicine,Nanjing,Jiangsu 210028,China)

机构地区：[1]南京中医药大学附属中西医结合医院麻醉科,江苏南京210028 [2]南京中医药大学附属中西医结合医院妇产科,江苏南京210028

出　　处：《医药前沿》2020年第31期11-13,共3页Journal of Frontiers of Medicine

基　　金：甘肃省人民医院院内科研基金项目一般项目:腹部提压心肺复苏新技术在急救中的应用。课题编号:18GSSY4-22。

摘　　要：目的:观察地佐辛复合丙泊酚对无痛人流术后疼痛及下腹坠胀等不良反应的影响。方法:选取2020年1月—3月在我院妇科门诊实施无痛人工流产术的患者160例,分为丙泊酚组(A组)、丙泊酚复合地佐辛组(B组)。A组予静脉推注丙泊酚2~3mg/kg;B组静脉滴注地佐辛50μg/kg,15分钟后静推丙泊酚2~2.5mg/kg。记录患者麻醉前(T0)、丙泊酚给药后2分钟后(T1)、手术开始后2分钟(T2)三个时刻的平均动脉压(MAP)、心率(HR)、血氧饱和度(Sp02);记录丙泊酚用药总量、患者苏醒时间;对人流术后患者VAS评分以及下腹坠胀进行评估。结果:两组患者麻醉后(T1),B组:MAP(84.25±7.96)mmHg、HR(78.00±8.33)次/分、Sp02(98.91%±0.81%)均明显高于A组:MAP(77.80±7.08)mmHg、HR(72.56±7.71)次/分、Sp02(98.15%±1.08%),差异有统计学意义(P<0.05);B组丙泊酚总用量(140.75±11.00)m g以及患者苏醒时间(4.94±0.77)分钟低于A组丙泊酚总用量(175.88±12.99)m g以及患者苏醒时间(7.39±1.13)分钟,差异有统计学意义(P<0.05);B组术后下腹痛情况明显好于A组;A组轻、中、重度疼痛人数分别为(44、33、3),B组为(71、9、0);A组患者出现下腹坠胀人数为32,坠胀伴有明显便意的患者人数为14,B组分别为13和1,B组显著低于A组(P<0.05)。结论:选择地佐辛配伍丙泊酚用于无痛人流术,患者术中循环更加稳定,术后腹痛及下腹坠胀感明显减轻,患者满意度更高。Objective To observe the effect of Dezocine combined with Propofol on adverse reactions such as abdominal pain and underbelly bulge after painless induced abortion.Methods A total of 160 women who underwent painless induced abortion in the gynecological outpatient department of our hospital from January 2020 to March 2020 were selected and divided into Propofol group(group1 A)and Propofol combined with Dezocine group(group B).Group A received intravenous Propofol injection of 2-3mg/kg.Group B received intravenous drip of Dezocine by 50μg/kg,and Propofol 2-2.5mg/kg was given intravenously.after 15 minutes.The mean arterial pressure(MAP),heart rate(HR),and blood oxygen saturation(Sp02)were recorded at three times:before anesthesia(T0),2 minutes after Propofol administration(T1),and 2 minutes after surgery(T2).The total amount of Propofol and the patient's recovery time were recorded.VAS score and underbelly bulge were evaluated after abortion.Results After anesthesia(T1),MAP(84.25±7.96mm Hg),HR(78.00±8.33 times/min)and Sp02(98.91±0.81%)in group B were significantly higher than those in group A:MAP(77.80±7.08mm Hg),HR(72.56±7.71 times/min)and Sp02(98.15±1.08%)(P<0.05).The total amount of Propofol in group B(140.75±11.00mg)and the patient's waking time(4.94±0.77 minutes)were significantly lower than the total amount of Propofol in group A(175.88±12.99mg)and the patient's waking time(7.39±1.13 minutes)(P<0.05).Compared with group A,the postoperative lower abdominal pain in group B was significantly improved.The number of mild,moderate and severe pain in group A was(44,33,3),and that in group B was(71,9,0).The number of patients in group A with abdominal distension was 32,the number of patients with distension accompanied by obvious defecation was 14,and the number of patients in group B was 13 and 1,respectively.The number of patients in group B was significantly lower than that in group A(P<0.05).Conclusion Dezocine combined with Propofol can be used in painless abortion,the intraoperative circulation is m

关 键 词：丙泊酚 地佐辛 无痛人流术 

分 类 号：R711[医药卫生—妇产科学]