不同麻前给药配合乳化七氟烷对矮马肾素-血管紧张素-醛固酮系统及无创血压影响的对比  

Comparison of the Effects of Different Premedication Combined with Emulsified Sevoflurane on Renin-angiotensin-aldosterone System and Noninvasive Blood Pressure in Pony

作　　者：杜垣逸 ALANCIA CAROL Clifton 刘娜 范玉莹 贾昊天 葛瑞东 李秀云[2] 邹希明[2] 刘云[1] DU Yuanyi;ALANCIA CAROL Cliftion;LIU Na;FAN Yuying;JIA Haotian;GE Ruidong;LI Xiuyun;ZOU Ximing;LIU Yun(College of Veterinary Medicine,Northeast Agricultural University,Harbin 150030,China;Harbin North Forest Zoo,Harbin 150000,China)

机构地区：[1]东北农业大学动物医学学院,哈尔滨150030 [2]哈尔滨北方森林动物园,哈尔滨150000

出　　处：《中国畜牧兽医》2021年第2期763-771,共9页China Animal Husbandry & Veterinary Medicine

基　　金：“十三五”国家重点研发计划专项课题(2016YFD051310)。

摘　　要：本试验旨在比较不同麻前给药方案配合乳化七氟烷进行麻醉时对矮马无创血压及肾素-血管紧张素-醛固酮系统(RAAS)的影响。以半野生矮马为研究对象,将10匹矮马随机分成KFXES组、KFDBES组两组,采用肌内注射的方式,KFXES组使用氯胺酮、静松灵、芬太尼对矮马进行诱导麻醉,KFDBES组使用氯胺酮、布托啡诺、右旋美托咪定和芬太尼对矮马进行诱导麻醉。矮马保持自主呼吸,采用静脉给药的方式,恒速静脉滴注6%乳化七氟烷维持麻醉2 h。在给药前记录常态下试验动物基础体征,在麻醉后持续2 h记录矮马的生命体征,分别于0、30、60、90、120 min监测无创血压,并同步采集血液样本,检测血浆中肾素、血管紧张素、醛固酮等因子的浓度。结果显示,在试验过程中,KFXES组矮马的血压与试验前对比有显著性差异(P<0.05),在0~60 min时,对RAAS的抑制性两试验组间无明显差异(P>0.05),麻醉时间超过90 min时,KFXES组对RAAS的抑制显著弱于KFDBES组(P<0.05)。因此,氯胺酮、芬太尼、布托啡诺及右旋美托咪定复合乳化七氟烷相对于氯胺酮、静松灵及芬太尼复合乳化七氟烷对半野生矮马进行麻醉时血压稳定性更好,在麻醉90 min后对RAAS的影响更大。本研究结果可为矮马的麻醉方法或剂量优化提供参考。The aim of this study was to compare the effects of different pre-anesthesia administration regimens combined with emulsified sevoflurane on non-invasive blood pressure and renin angiotensin aldosterone system(RAAS).Ten semi-wild ponies were randomly divided into two groups,KFXES and KFDBES.The ponies were anesthetized(ketamine,Jingsongling and fentanyl were used in KFXES group,while ketamine,butorphanol,dexmedetomidine and fentanyl were used in KFBES group)by intramuscular injection.The ponies maintained spontaneous respiration and maintained anesthesia for 2 h by intravenous infusion of 6%emulsified sevoflurane at constant speed.Before administration,the basic physical signs of ponies were recorded under normal condition,and the vital signs were continuously recorded for more than 2 hours after anesthesia.Noninvasive blood pressure was monitored at 0,30,60,90 and 120 min,and blood samples were taken simultaneously to detect the concentrations of renin,angiotensin,aldosterone and other factors in plasma.The results showed that,in the course of the experiment,the blood pressure of the ponies in KFXES group was significantly different from that before the test(P<0.05).At 0-60 min,the inhibition to RAAS between two groups had no significant difference(P>0.05).When the anesthesia time was more than 90 min,the inhibition of KFXES group on RAAS system was significantly weaker than that of KFDBES group(P<0.05).Therefore,ketamine,fentanyl,butorphanol and dexmedetomidine combined emulsified sevoflurane had better blood pressure stability than ketamine,Jingsongling and fentanyl combined emulsified sevoflurane,and had a greater impact on RAAS after 90 min.The results of this study could provide data support and direction guidance for the optimization of anesthesia method or dose of pony.

关 键 词：矮马 麻醉 肾素-血管紧张素-醛固酮系统(RAAS) 乳化七氟烷 

分 类 号：S859.791[农业科学—临床兽医学]