Visible-light induced generation of bifunctional nitrogen-centered radicals:a concise synthetic strategy to construct bicyclo[3.2.1]octane and azepane cores  

作　　者：Wan-Lei Yu Hao-Wen Jiang Lei Yan Zhi-Tao Feng Yong-Chun Luo Peng-Fei Xu 

机构地区：[1]State Key Laboratory of Applied Organic Chemistry,College of Chemistry and Chemical Engineering,Lanzhou University,Lanzhou,730000,China [2]Department of Chemistry,University of California-Davis,One Shields Avenue,Davis,CA,95616,USA

出　　处：《Science China Chemistry》2021年第2期274-280,共7页中国科学（化学英文版）

基　　金：the National Natural Science Foundation of China(21632003,21871116);the Key Program of Gansu Province(17ZD2GC011);the‘‘111’’Program from the MOE of China。

摘　　要：A photocatalytic tandem cyclization of o-alkenylbenzaldehydes using pyridinium salts as the amination reagent is described.A variety of valuable seven-membered nitrogenous heterocyclic skeletons are prepared in modest to excellent yields in concise one-step.This transformation features mild reaction conditions and exceptional functional group tolerance.In addition,combining control experiments and density functional theory(DFT)calculations on the mechanism can explain the reaction selectivity.

关 键 词：photoredox catalysis nitrogen-centered radicals bicyclo[3.2.1]octane azepane 1 5-hydrogen atom transfer 

分 类 号：O626[理学—有机化学]