注射用尖吻蝮蛇血凝酶对后路腰椎手术切口止血作用的效果评价  

Evaluation of hemostatic effect of Agkistrodon acutus hemocoagulase for injection on incision of posterior lumbar surgery

作　　者：冯浩[1] 陈焕诗[1] 白瑞飞[1] 李伟 易军飞[1] FENG Hao;CHEN Huan-shi;BAI Rui-fei;LI Wei;YI Jun-fei(Liuzhou Liutie Central Hospital,Guangxi Liuzhou 545007)

机构地区：[1]柳州市柳铁中心医院,广西柳州545007

出　　处：《临床医药文献电子杂志》2020年第102期5-6,共2页Electronic Journal of Clinical Medical Literature

基　　金：尖吻蝮蛇血凝酶对后路腰椎手术切口止血作用的临床研究,合同编号:Z20170030。

摘　　要：目的研究对后路腰椎手术切口止血使用注射用尖吻蝮蛇血凝酶(HCA)的应用效果。方法在本院选取60例实施后路腰椎手术治疗患者,资料源自2017年2月~2019年6月,使用随机数字表法分为两组,各30例,术前15min静脉注射注射用HCA2U为A组,术前15min静脉注射生理盐水2ml为B组,对比两组治疗后临床效果。结果对比B组,A组止血时间短,出血量、单位面积出血量均较少(P<0.05);A组与B组凝血功能指标、肝肾功能指标对比均无明显差异(P>0.05);两组无不良事件发生。结论对后路腰椎手术患者给予HCA具有良好的止血效果,能明显缩短手术切口的出血时间,减少手术切口的出血量,并对机体凝血功能、肝功能及肾功能无明显影响,是一种安全有效的止血药物,值得借鉴。Objective To study the effect of injection of HCA for hemostasis in posterior lumbar spine incision.Methods A total of 60 patients undergoing posterior lumbar surgery were selected from our hospital.The data were from February 2017 to June 2019.The randomized number table method was used to divide the patients into two groups,each with 30 cases.Results Compared with group B,group A had shorter hemostasis time and less blood loss per unit area(P<0.05).There was no significant difference in coagulation function,liver and kidney function between group A and group B(P>0.05).No adverse events occurred in the two groups.Conclusion HCA has a good hemostatic effect in patients undergoing posterior lumbar surgery,can significantly shorten the bleeding time of the surgical incision,reduce the amount of blood loss of the surgical incision,and has no obvious effect on the body's coagulation function,liver function and renal function.It is a safe and effective hemostatic drug and is worthy of reference.

关 键 词：后路腰椎手术 止血 尖吻蝮蛇血凝酶 生理盐水 凝血功能 

分 类 号：R917[医药卫生—药物分析学]