阿尔茨海默病动物模型建立及评价研究分析  

Research and analysis on the establishment and evaluation of animal models of Alzheimer disease

作　　者：邓婷 谢丹妮[1,2] 王平 李劲松[3] 徐颖[1,2] 孙涛[1,2] DENG Ting;XIE Dan-ni;WANG Ping;LI Jing-song;XU Ying;SUN Tao(Key Laboratory of Standardization for Chinese Herbal Medicine,Ministry of Education,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China;Key Laboratory of Distinctive Chinese Medicine Resources in Southwest China,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China;The First People′s Hospital of Guangyuan,Guangyuan 628017,China)

机构地区：[1]成都中医药大学中药材标准化教育部重点实验室,四川成都611137 [2]成都中医药大学西南特色中药资源国家重点实验室,四川成都611137 [3]广元市第一人民医院,四川广元628017

出　　处：《中国药理学与毒理学杂志》2020年第11期847-856,共10页Chinese Journal of Pharmacology and Toxicology

基　　金：国家自然科学基金(81773906);四川省教育厅重点项目(17ZA0152);四川省教育厅重点项目(18ZA0179);广元市科技局科技支撑计划项目(14KJZCS003);四川省科技厅应用基础项目(2021YJ0178)。

摘　　要：目前阿尔茨海默病(AD)动物模型主要有氧化应激损伤、胆碱能损伤、铝中毒、β-淀粉样蛋白毒性和转基因等,其在造模周期、成功率等方面各具特点。本文通过整理近年建立AD动物模型的相关文献,以AD病因及病理机制为核心,总结并分析AD动物建模方法及评价指标,以期对AD模型进行合理的方法学评价。笔者认为,在现有AD动物模型的研究基础上,应结合新型的转基因技术和生物技术,构建与临床相符的AD模型症状,并参考AD临床诊断标准对动物模型的相关指标进行评价,将有利于全面评价AD模型。Alzheimer disease(AD)animal models mainly involve oxidative stress damage,cholinergic damage,aluminum poisoning,β-amyloid toxicity,and transgenic animals.These models have different characteristics that are mainly reflected in the modeling cycle and molding rate.By sorting out the related literature on AD modeling in recent years and focusing on the etiology and pathogenesis of AD,this paper summarizes and analyzes the methods of constructing AD models and evaluation indices,in order to make a proper methodological evaluation of AD models.It is believed that based on the research of existing AD models,new transgenic technology and biotechnology should be used to produce symptoms of the AD model that are consistent with the clinical practice.At the same time,the related indicators of animal models should be evaluated with reference to the clinical diagnostic standards of AD,which is conducive to comprehensive evaluation of AD models.

关 键 词：阿尔茨海默病 动物模型 评价方法 

分 类 号：R964[医药卫生—药理学]