儿童药物利用指数评价伏立康唑在儿童用药合理性  

Evaluation on Rational Use of Voriconazole for Children by Children Drug Utilization Index

作　　者：丁翔宇[1] 刘艳辉[1] 贾晨虹 张古英[1] 王磊 DING Xiangyu;LIU Yanhui;JIA Chenhong;ZHANG Guying;WANG Lei(Department of Pharmacy,Children’s Hospital of Hebei Province,Shijiazhuang 050031,China;Office of Asset Management,Children’s Hospital of Hebei Province,Shijiazhuang 050031,China)

机构地区：[1]河北省儿童医院药学部,石家庄050031 [2]河北省儿童医院资产管理处,石家庄050031

出　　处：《医药导报》2021年第3期398-400,共3页Herald of Medicine

基　　金：河北省卫健委医学科学研究课题计划(20190810)。

摘　　要：目的建立儿童药物利用评价方法,应用儿童药物利用指数(cDUI)评价伏立康唑在儿童中用药剂量的合理性。方法对2015年1月—2019年6月使用伏立康唑的出院儿童患者病历进行回顾性分析,按照体质量分组,计算cDUI。结果按负荷剂量给药方案计算,伏立康唑口服剂型与注射剂型各体质量组cDUI基本接近1(伏立康唑口服剂型体质量<10 kg组cDUI为1.27,提示该组用药剂量偏大)。以非负荷剂量给药方案计算,伏立康唑口服剂型与注射剂型各体质量组cDUI普遍<0.8(伏立康唑注射剂型体质量<10 kg组cDUI为0.94),伏立康唑注射剂型体质量>40 kg组低至0.55。结论负荷剂量给药组伏立康唑给药剂量基本合理,非负荷剂量给药组剂量偏小,cDUI方法的建立是一个探索的过程,虽然现有的体系与方法仍存在一些缺陷,但在评估儿童用药剂量合理性方面仍有一定可行性。Objective To establish a method for evaluation of drug use in children and to evaluate the rationality of voriconazole dosage in children by children drug utilization index(cDUI).Methods Retrospective analysis was carried out on the cases of discharged children who were treated with voriconazole from January 2015 to June 2019.The children were grouped according to bady mass,and the cDUI was calculated.Results According to the method of loading dose administration,the cDUI of the oral form and injection form of voriconazole was basically close to 1 in each body mass group(except that the cDUI of the oral form of voriconazole lower than 10 kg group was 1.27,indicating that the dose of this group was relatively large).However,the cDUI of all the body mass groups without load dosage method was generally lower than 0.8(except that the cDUI of the injection voriconazole of the body mass lower than 10 kg group was 0.94),and the cDUI of the injection voriconazole was even as low as 0.55 in the>40 kg group.Conclusion The dose of voriconazole in the load dose group was basically reasonable,while the dose in the non-load dose group is relatively small.The establishment of cDUI method is an exploratory process.Although there are still some defects in this system and methods,it is still feasible to evaluate the rationality of dosage in children.

关 键 词：伏立康唑 儿童药物利用指数 剂量 合理用药 

分 类 号：R978.1[医药卫生—药品] R969[医药卫生—药学]