A Highly Efficient Aggregation-induced Emission Photosensitizer for Photodynamic Combat of Multidrug-resistant Bacteria  

作　　者：ZOU Qian WANG Jia-Li WU Ming-Yu KAM LEE Sin-Ying FENG Shun CHEN Sijie 

机构地区：[1]School of Life Science and Engineering,Southwest Jiaotong University,Chengdu,610031,P.R.China [2]Ming Wai Lau Centre for Reparative Medicine,Karolinska Institutet,Hong Kong,P.R.China

出　　处：《Chemical Research in Chinese Universities》2021年第1期150-156,共7页高等学校化学研究（英文版）

基　　金：This work was supported by the National Natural Science Foundation of China(No.21708030);the Start-up Funding from Ming Wai Lau Centre for Reparative Medicine,Karolinska Institutet.

摘　　要：With the antibiotic abuse and the resulting increased antibiotic resistance,the bacterial infection has posed a serious threat to human health.Photodynamic therapy is an effective tool for treating localized and superficial infections.It is a promising approach for the treatment of superbugs and with minimal risk of induced antibiotic resistance.Herein,an isoquinolinium-based photosensitizer,LIQ-TPE,with aggregation-induced emission properties is designed and synthesized.It is with high 1O2 generation efficiency and shows efficient antibacterial performance towards both Gram-negative and Gram-positive bacteria,and even methicillin-resistant Staphylococcus aureus(MRSA).LIQ-TPE thus shows great promise as an effective antimicrobial agent to combat the menace of multi-drug resistant bacteria.

关 键 词：Aggregation-induced emission PHOTOSENSITIZER Isoquinolinium Photodynamic antibiosis 

分 类 号：O6[理学—化学]