A Novel Fluorescent Probe for ATP Detection Based on Synergetic Effect of Aggregation-induced Emission and Counterion Displacement  

作　　者：PAN Quan MA Feiyan PU Xinqing ZHAO Manyi WU Qiling ZHAO Na YANG Jun TANG Ben Zhong 

机构地区：[1]Key Laboratory of Macromolecular Science of Shaanxi Province,School of Chemistry&Chemical Engineering,Shaanxi Normal University,Xi’an,710119,P.R.China [2]Department of Chemistry,The Hong Kong University of Science&Technology(HKUST),Clear Water Bay,Kowloon,Hong Kong,P.R.China

出　　处：《Chemical Research in Chinese Universities》2021年第1期166-170,共5页高等学校化学研究（英文版）

基　　金：This work was supported by the National Natural Science Foundation of China(No.21975149);the Funded Projects for the Academic Leaders and Academic Backbones,Shaanxi Normal University,China(No.18QNGG007);the Fundamental Research Funds for the Central Universities of China(No.GK202003036).

摘　　要：In this work,a fluorescent probe(TPEBe-I)was developed for adenosine triphosphate(ATP)detection based on the synergetic effect of aggregation-induced emission and counterion displacement.TPEBe-I gave weak emission in aqueous solution due to the heavy-atom effect of counter iodide ion.However,upon the addition of ATP,the new aggregate complex(TPEBe-ATP)was formed between the cationic unit of TPEBe-I and ATP through electrostatic interactions,which not only restricted the intramolecular motion of luminogen but also eliminated the quenching effect of iodide ion.As a result,the fluorescent light-up detection for ATP was successfully achieved.Moreover,TPEBe-I exhibited high selectivity towards ATP and showed a wide linear detection region towards the logarithm of ATP concentration(5—600µmol/L)with a detection limit of 1.0µmol/L,enabling TPEBe-I as a promising probe for ATP quantitative analysis.

关 键 词：Fluorescent probe Adenosine triphosphate Aggregation-induced emission Counterion displacement 

分 类 号：O62[理学—有机化学]