间充质干细胞对胰岛移植物的保护作用机制研究进展  

Research progress on the protective mechanism of mesenchymal stem cells on islet grafts

作　　者：李峰 李晓航[1] 张佳林[1] Li Feng;Li Xiaohang;Zhang Jialin(Hepatobiliary Surgery Department,the First Hospital of China Medical University,Shenyang 110001,China)

机构地区：[1]中国医科大学附属第一医院肝胆外科,沈阳110001

出　　处：《中华移植杂志（电子版）》2020年第6期397-400,共4页Chinese Journal of Transplantation(Electronic Edition)

基　　金：辽宁省重点研发计划指导项目(2017225031)。

摘　　要：胰岛移植被认为是治疗1型糖尿病及部分2型糖尿病最为有效的方法,但目前其临床疗效有待进一步提高。已有大量文献报道间充质干细胞(MSCs)对胰岛移植物具有保护作用,但其具体机制尚不完全清楚。本文就已报道的MSCs对胰岛移植物的营养作用、促进胰岛移植物再血管化、免疫调节及调控内质网应激4个方面的研究进展做一综述。Islet transplantation is considered to be the most effective method for the treatment of type 1 diabetes and some type 2 diabetes,but its clinical efficacy needs to be further improved.A large number of literatures have reported that mesenchymal stem cells(MSCs)have a protective effect on islet grafts,but its specific mechanism is unclear.This article summarizes the reported protective effects of MSCs on islet grafts into four aspects:nutritional effects,promotion of revascularization,immune regulation,and regulation of endoplasmic reticulum stress.

关 键 词：间充质干细胞 胰岛 胰岛移植 糖尿病 

分 类 号：R587.2[医药卫生—内分泌]