NT-proBNP水平对非ST抬高型急性冠脉综合征患者冠脉闭塞病变的诊断价值  

Diagnostic value of NT-proBNP level forcoronary artery occlusion in patients with non-ST-elevation acute coronary syndrome

作　　者：吴珂[1] 向兵 周后强 张明亮[1] 齐新颜[1] 张焕轶[1] WU Ke;XIANG Bing;ZHOU Hou-qiang;ZHANG Ming-liang;QI Xin-yan;ZHANG Huan-yi(Cardiovascular Center, Tai’an Central Hospital, Tai’an 271000, Shandong, China)

机构地区：[1]泰安市中心医院心脏血管中心,泰安271000

出　　处：《中国临床医学》2021年第1期85-89,共5页Chinese Journal of Clinical Medicine

基　　金：山东省泰安市科技发展计划项目(2018NS0170).

摘　　要：目的:探讨N端脑钠肽前体(NT-proBNP)水平与非ST抬高型急性冠脉综合征(NSTE-ACS)患者冠状动脉闭塞病变的相关性及对病变的评估价值。方法:选取2017年12月至2019年12月泰安市中心医院收治的NSTE-ACS患者223例,根据冠脉造影的结果分为非闭塞病变组(n=156)和闭塞病变组(n=67)。分析2组NT-proBNP水平差异,采用logistic回归分析闭塞病变的危险因素,采用受试者工作特征(ROC)曲线评估NT-proBNP对闭塞病变的诊断价值。结果:与非闭塞病变组相比,闭塞病变组NT-proBNP水平显著升高,差异有统计学意义(P<0.001);多因素logistic回归分析显示,NT-proBNP水平升高是NSTE-ACS闭塞病变的危险因素(OR=1.011,95%CI 1.001~1.012,P=0.002)。NT-proBNP诊断闭塞病变的ROC曲线下方面积(AUC)为0.724(95%CI0.638~0.810),最佳界值点为149.50 ng/L,灵敏度为80.6%,特异度为61.5%。结论:在NSTE-ACS闭塞病变中,NT-proBNP水平升高,对NSTE-ACS的闭塞病变有一定诊断价值。Objective:To explore the correlation between NT-proBNP level and coronary artery occlusion in patients with the non-ST-elevation acute coronary syndrome(NSTE-ACS)and its evaluation value.Methods:223 patients with NSTE-ACS admitted to Tai’an Central Hospital from December 2017 to December 2019 were selected.According to the results of coronary angiography,the patients were divided into non occlusive disease group(n=156)and occlusive disease group(n=67).The NT-proBNP level of the two groups was measured and compared.The risk factors of coronary occlusion were analyzed by logistic regression,and the diagnostic value of NT-proBNP for NSTE-ACS occlusive lesions was evaluated by ROC curve.Results:Compared with the non-coronary occlusion group,the level of NT-proBNP in the coronary occlusion group was significantly higher(P<0.001);multivariate logistic regression analysis showed that high level of NT-proBNP was an independent risk factor for the presence of coronary occlusion in NSTE-ACS(OR=1.011,95%CI 1.001-1.012,P=0.002).The area under ROC curve of NT-proBNP was 0.724(95%CI 0.638-0.810),and the best cut-off point was 149.50 ng/L,sensitivity 80.6%,specificity 61.5%.Conclusions:In NSTE-ACS patients with coronary occlusion,the level of NT-proBNP is increased.It is of certain value to the diagnosis of NSTE ACS occlusion.

关 键 词：N端脑钠肽前体 非ST抬高型急性冠状动脉综合征 冠脉闭塞 

分 类 号：R543.3[医药卫生—心血管疾病]