GC与MVAC新辅助化疗方案治疗局部转移性膀胱癌患者的效果比较  

Comparison of effects of GC and MVAC neoadjuvant chemotherapy regimens intreatment of patients with locally metastatic bladder cancer

作　　者：任铁刚 REN Tiegang(Department of Oncology of Xingcheng People’s Hospital,Xingcheng 125100 Liaoning,China)

机构地区：[1]辽宁省兴城市人民医院肿瘤科,辽宁兴城125100

出　　处：《中国民康医学》2021年第2期122-123,126,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:比较GC(吉西他滨+顺铂)与MVAC(长春花碱+氨甲蝶呤+多柔比星+顺铂)辅助化疗方案治疗局部转移性膀胱癌患者的效果。方法:回顾性分析2015年4月至2017年4月该院收治的120例局部晚期膀胱癌患者的临床资料,按治疗方法不同分为对照组和研究组各60例。对照组采用MVAC辅助化疗方案治疗,研究组采用GC辅助化疗方案治疗,比较两组化疗前后肿瘤直径、复发率、无瘤生存期和不良反应发生率。结果:化疗后,研究组肿瘤直径小于对照组,差异有统计学意义(P<0.05);研究组复发率低于对照组,无瘤生存期长于对照组,差异均有统计学意义(P<0.05);研究组不良反应发生率为30.00%(18/60),低于对照组的51.67%(31/60),差异有统计学意义(P<0.05)。结论:GC辅助化疗方案治疗局部转移性膀胱癌患者可缩小肿瘤直径,降低复发率和不良反应发生率,以及延长无瘤生存期,其效果优于MVAC辅助化疗方案。Objective:To compare effects of GC(Gemcitabine+Cisplatin)and MVAC(Vinblastine+Methotrexate+Doxorubicin+Cisplatin)neoadjuvant chemotherapy regimens in treatment of patients with locally metastatic bladder cancer.Methods:A retrospective analysis of the clinical data of 120 patients with locally advanced bladder cancer admitted to our hospital from April 2015 to April 2017 was performed.According to different treatment methods,they were divided into control group and study group,each with 60 cases.The control group was treated with MVAC adjuvant chemotherapy,while the study group was treated with GC adjuvant chemotherapy.The tumor diameters before and after the chemotherapy,recurrence rate,tumor-free survival and incidence of adverse reactions were compared between the two groups.Results:After the chemotherapy,the tumor diameter of the study group was smaller than that of the control group,and the difference was statistically significant(P<0.05).The recurrence rate of the study group was lower than that of the control group;the tumor-free survival period was longer than that of the control group;and the differences were statistically significant(P<0.05).Further,the incidence of adverse reactions in the study group was 30.00%(18/60),lower than that in the control group of 51.67%(31/60),and the difference was statistically significant(P<0.05).Conclusions:GC-adjuvant chemotherapy for the patients with locally metastatic bladder cancer can reduce the tumor diameter,reduce the recurrence rate and the incidence of adverse reactions,and prolong the tumor-free survival.Moreover,it is superior to MVAC adjuvant chemotherapy.

关 键 词：吉西他滨 顺铂 局部转移性膀胱癌 复发率 不良反应 

分 类 号：R737.14[医药卫生—肿瘤]