半红树植物黄槿内生菌及其代谢产物的研究进展  

Research progress on endophytes from semi-mangrove plant Hibiscus tiliaceus and its metabolites

作　　者：蒋圆婷 刘杨 陈德力[2,3] 梁寒峭 JIANG Yuan-ting;LIU Yang;CHEN De-li;LIANG Han-qiao(Department of biomedicine,Beijing City University,Beijing 100083,China;Hainan Branch Institute of Medicinal Plant Development(Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine),Chinese Academy of Medical Sciences&Peking Union Medical College,Haikou 570311,China;Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100193,China)

机构地区：[1]北京城市学院生物医药学部,北京100083 [2]中国医学科学院北京协和医学院药用植物研究所,海南分所海南省南药资源保护与开发重点实验室,海口570311 [3]中国医学科学院北京协和医学院药用植物研究所,北京100193

出　　处：《天然产物研究与开发》2021年第2期331-341,共11页Natural Product Research and Development

基　　金：国家自然科学基金(81603387);北京城市学院科研发展基金(KYF202003);北京城市学院2020年度研究生科研创新项目(Yjscx202010)。

摘　　要：黄槿(Hibiscus tiliaceus)为锦葵科(Malvaceae)木槿属(Hibiscus)泛热带的半红树植物,具有清热止咳、解毒消肿等功效。黄槿内生菌可产生与宿主植物相同或相似的化学结构,且其代谢产物中含有结构新奇的活性分子。目前,从黄槿内生菌中分离鉴定出多种内生菌种类,包括赤散囊菌(Eurotium rubrum)、团青霉菌(Penicillium commune)、草酸青霉(Penicillium oxalicum)、镰刀属(Fusarium sp.)真菌等。其内生菌代谢产物,主要活性成分为生物碱类、核苷类、蒽醌类、多取代苯类和三萜类等。现代药理学研究表明黄槿内生菌代谢产物具有抗菌、抗肿瘤、抗炎等多种药理活性。该文综述了近二十年黄槿内生菌的研究现状及其代谢产物和药理活性研究进展,以期为半红树植物黄槿及其内生菌的药用价值开发应用提供科学依据和参考。Hibiscus tiliaceus(Hibiscus sp.,Malvaceae),the semi-mangrove plant,located in the tropics.It possesses the effects in clearing heat and relieving cough,detoxifying and swelling.The same or similar structures as the host plants can be produced from H.tiliaceus endophytes,and its metabolites have novel active molecules.Currently,a variety of endophytic species have been isolated and identified,which included Eurotium rubrum,Penicillium commune,Penicillium oxalicum,Fusarium sp..Pharmacological activities of metabolites from H.tiliaceus endophytes were summarized,and alkaloids,nucleoside compounds,anthraquinones,polysubstituted benzene compounds,triterpenoids,etc.have been obtained.Modern pharmacological studies show that the metabolites of H.tiliaceus endophytes have antibacterial,anti-tumor,anti-inflammation and other pharmacological activities.This paper reviews the research status of H.tiliaceus endophytes and its metabolic products and pharmacological activity in recent 20 years.This review also aims to provide scientific basis and reference for the development and application of the medicinal value of the semi-mangrove plant H.tiliaceus.

关 键 词：黄槿 内生菌 多样性 代谢产物 药理活性 

分 类 号：R931[医药卫生—生药学]