毛囊发育与周期性生长的调控信号通路研究进展  

Progress in research on the regulatory signaling pathway of hair follicle development and periodic growth

作　　者：刘公言 白莉雅[1] 李福昌[2] 孙海涛[1] 杨丽萍[1] 姜文学[1] 高淑霞[1] LIU Gongyan;BAI Liya;LI Fuchang;SUN Haitao;YANG Liping;JIANG Wenxue;GAO Shuxia(Animal Husbandry and Veterinary Institute,Shandong Academy of Agricultural Sciences/Shandong Province Key Laboratory of Animal Disease Control and Breeding,Ji’nan 250100,China;College of Animal Science and Technology,Shandong Agricultural University,Tai'an 271018,China)

机构地区：[1]山东省农业科学院畜牧兽医研究所/山东省畜禽疫病防治与繁育重点实验室,山东济南250100 [2]山东农业大学动物科技学院,山东泰安271018

出　　处：《畜牧与兽医》2021年第1期125-129,共5页Animal Husbandry & Veterinary Medicine

基　　金：国家自然科学基金(31972594);山东省自然科学基金(ZR2018MC025);山东省现代农业产业技术体系特种经济动物创新团队建设项目(SDAIT-21);2017年省农业良种工程(南种北繁)项目(2017LZN008);山东省农业重大应用技术创新兔舍环境测控设备及大数据分析应用平台项目(SF1805301301)。

摘　　要：毛囊是皮肤的重要附属结构,也是控制哺乳动物被毛生长的重要器官。哺乳动物出生后,毛囊具有终生呈周期性生长的特性,毛囊干细胞、毛乳头细胞、毛母质细胞及脂肪细胞等参与了毛囊周期性生长,Wnt、BMP、Notch等信号通路与毛囊生长发育密切相关。本文从哺乳动物毛囊的结构、周期性生长特征以及参与毛囊周期性生长调控的相关信号通路等进行了详细阐述,为深入了解哺乳动物毛囊的周期性生长调控机制,以及为今后指导绒山羊、绵羊、长毛兔等毛用动物和獭兔、水貂、狐狸、貉等皮用动物选育和提高生产性能提供理论参考。Hair follicle is an important appendage structure of skin and plays an important role in controlling hair growth.After their birth,mammals’hair follicles have the characteristics of periodic growth throughout their lives;and thei hair follicle stem cells,dermal papilla cells,hair matrix cells and fat cells participate in the periodic growth of the hair follicles.Furthermore,Wnt,BMP,Notch and other signaling pathways are closely related to the development and periodic growth of the hair follicle.In order to understand the development mechanism of mammalian hair follicles,we have described,in this review,the structure and characteristics of hair follicles,the growth characteristics of hair follicles after birth of mammalians,and signal transduction pathways involved in the periodic circulation of hair follicles,in the hope of providing theoretical reference for wool and fur animal breeding and production improvement in the future.

关 键 词：毛囊 周期性生长 调控 信号通路 

分 类 号：S829.1[农业科学—畜牧学]