电子疫苗热敏感标签监测效果评价  

Evaluation on monitoring effect of the electronic vaccine vial monitor label

作　　者：陈小芳[1] 刘建忠 姚千予 陈贤义 CHEN Xiaofang;LIU Jianzhong;YAO Qianyu;CHEN Xianyi(Suzhou Industrial Park Centers for Disease Control and Prevention,Suzhou,Jiangsu 215021,P.R.China;Beijing Zhongyi Health Research Institute,Beijing 100089,P.R.China;University of Melbourne,Parkville,Victoria 3010,Australia)

机构地区：[1]苏州工业园区疾病防治中心,江苏苏州215021 [2]中义(北京)健康研究院,北京100089 [3]墨尔本大学,澳大利亚维多利亚州墨尔本3010

出　　处：《生物医学工程学杂志》2021年第1期154-160,共7页Journal of Biomedical Engineering

基　　金：国家重大专项(2018ZX10101001-002-003);苏州市科技局项目(SS2019023)。

摘　　要：疫苗的冷链安全为全球性问题,电子疫苗热敏感标签(eVVM)可对疫苗温度进行实时监控,并进行"预警"提示。为综合评价eVVM的监测效能,本研究在不同产品批次中随机抽取75个eVVM标签,将其与四种不同类型共600个疫苗温度指示标签(VVM)平均分配到不同的实验环境中(2~8℃、-20℃以及40℃),采用温度记录仪作为对照。结果显示,eVVM标签、VVM标签在高温温度监测方面的精确度与温度记录仪具有很好的一致性(P=0.195),且eVVM标签在低温异常和高温异常的正确率均为100%,优于VVM标签。因此,我们认为eVVM标签有较高的精确度,对于进一步提高冷链的监测效率及准确度均具有良好的应用前景。The cold chain safety of vaccines is a global issue.The electronic vaccine vial monitor(eVVM)label can monitor the temperature of vaccines in real time and provide"early warning"prompts.In order to comprehensively evaluate the monitoring efficiency of eVVM,this study selected 75 eVVM labels and distributed them with a total of 600 vaccine vial monitor(VVM)labels of four different types in different experimental environment(2-8℃,-20℃and 40℃),and used a temperature recorder as"gold standard".The results showed that the accuracy of the eVVM labels and VVM labels in high temperature environment was as same as that of the temperature recorder(P=0.195).The accuracy of low temperature anomalies report and high temperature anomalies report of eVVM labels was 100%,which was better than those reported by VVM labels.Therefore,eVVM labels have high monitoring accuracy,which is suitable not only for ordinary environments,but also for severe temperature environments.It should be helpful for the improvement of the efficiency and accuracy of cold chain monitoring.

关 键 词：疫苗 热敏感 标签 

分 类 号：R392-3[医药卫生—免疫学]