丙泊酚复合舒芬太尼清醒镇静与丙泊酚深度镇静在鼾症患者胃镜检查中不良反应及术后疲劳综合征的比较  

Comparison of adverse reactions and postoperative fatigue syndrome between propofol combined with sufentanil for conscious sedation and propofol for deep sedation during gastroscopy in patients with snoring

作　　者：康帅[1] 胡立 路建[1] 吴城[1] 周红梅[1] KANG Shuai;HU Li;LU Jian;WU Cheng;ZHOU Hongmei(Department of Anesthesology,Second Affiliated Hospital,Jiaxing University,Jiaxing 314000,China)

机构地区：[1]浙江省嘉兴学院附属第二医院麻醉科,嘉兴314000

出　　处：《中国临床药学杂志》2021年第1期5-8,共4页Chinese Journal of Clinical Pharmacy

基　　金：嘉兴市科技计划项目(编号2019AD32148)。

摘　　要：目的观察丙泊酚复合舒芬太尼清醒镇静能否降低鼾症患者胃镜检查中不良反应及术后疲劳综合征(POFS)的发生率。方法共纳入胃镜检查的鼾症患者133例,随机分成清醒镇静组和深度镇静组。清醒镇静组采用丙泊酚复合舒芬太尼麻醉,深度镇静组采用传统丙泊酚麻醉。观察术中、术后不良反应,前者包括缺氧、呛咳、低血压、心动过缓,后者包括眩晕、头痛、恶心、呕吐、视力模糊、幻觉等,计算POFS发生率、初始疲劳评分和POFS持续时间。结果术中,清醒镇静组缺氧发生率显著低于深度镇静组(6.6%vs 19.0%,P <0.05),而呛咳发生率组间差异无统计学意义(29.5%vs 17.2%,P> 0.05)。术后,清醒镇静组恶心发生率显著高于深度镇静组(24.6%vs 10.3%,P <0.05),眩晕发生率也显著高于深度镇静组(36.1%vs 15.5%,P <0.05),而POFS发生率显著低于深度镇静组(18%vs 34.5%,P <0.05),初始疲劳评分也显著低于深度镇静组(4.3±1.5 vs 6.4±1.7,P <0.05)。结论丙泊酚复合舒芬太尼清醒镇静能降低鼾症患者在胃镜检查期间不良反应发生率和POFS发生率及严重程度,是鼾症患者行胃镜检查的良好选择。AIM To observe whether propofol combined with sufentanil for conscious sedation can reduce the incidence of adverse reactions and postoperative fatigue syndrome(POFS) in patients with snoring during gastroscopy. METHODS A total of 133 patients with snoring undergoing gastroscopy were included in the study, and they were randomly divided into conscious sedation group and deep sedation group respectively. The conscious sedation group received propofol combined with sufentanil, and the deep sedation group received traditional propofol. The intraoperative adverse reactions, including hypoxia, choking, hypotension, bradycardia, and postoperative adverse reactions including dizziness, headache, nausea, vomiting, blurred vision, and hallucinations, etc., as well as the incidence of POFS and initial fatigue score and POFS duration were observed. RESULTS The incidence of hypoxia in the conscious sedation group was significantly lower than that in the deep sedation group(6.6% vs 19.0%, P = 0.042). There was no significant difference in the incidence of choking between 2 groups(29.5% vs 17.2%, P > 0.05). The incidence of postoperative nausea and dizziness in the conscious sedation group was significantly higher than that in the deep sedation group(24.6% vs 10.3% and 36.1% vs 15.5%, P < 0.05). The incidence of POFS in the conscious sedation group was significantly lower than that of the deep sedation group(18% vs 34.5%, P < 0.05), and the initial fatigue score was significantly lower than that of the deep sedation group(4.3±1.5 vs 6.4±1.7, P < 0.05). CONCLUSION Propofol combined with sufentanil for conscious sedation can reduce the adverse reactions and the incidence of POFS and the severity of POFS in patients with snoring during gastroscopy, and it is a good choice for patients with snoring undergoing gastroscopy.

关 键 词：胃镜检查 清醒镇静 鼾症 不良反应 疲劳综合征 

分 类 号：R614[医药卫生—麻醉学]