内蒙古在校大学生体质量指数与肠道菌群宏基因组浓度的关联  

Correlation between BMI and metagenomics concentration of gut microbiota of college students in Inner Mongolia

作　　者：徐欣蕊 王新雨 张婧 耿艺昆 边浩东 吴迎旭 刘艳超 XU Xinrui;WANG Xinyu;ZHANG Jing;GENG Yikun;BIAN Haodong;WU Yingxu;LIU Yanchao(First Clinkal Medical College,Inner Mongolia Medical University,Huhhot(010110),China;不详)

机构地区：[1]内蒙古医科大学第一临床医学院,呼和浩特010110 [2]内蒙古医科大学公共卫生学院

出　　处：《中国学校卫生》2021年第1期106-108,共3页Chinese Journal of School Health

基　　金：内蒙古医科大学“三位一体”大学生创新创业培育项目(SWYT2018027)。

摘　　要：目的探索内蒙古地区在校大学生体质量指数(BMI)与肠道菌群的关联性,为揭示肠道菌群与肥胖之间的关联性提供参考依据。方法以内蒙古医科大学为试点,通过招募方式共收集88名志愿者。测量研究对象的身高和体重,并收集粪便样本。提取干粪便样本中的细菌宏基因组,并检测干粪便细菌宏基因组质量浓度(μg/μL)。统计分析BMI与肠道菌群宏基因组质量浓度的相关性,并比较不同BMI组的肠道菌群宏基因组质量浓度差异。结果大学生BMI与肠道菌群的宏基因组质量浓度呈负相关(r=-0.27,P<0.05)。不同BMI大学生的肠道菌群宏基因组质量浓度差异有统计学意义(F=3.62,P<0.05)。分性别分析,女生中,不同BMI的肠道菌群宏基因组质量浓度差异有统计学意义(F=1.87,P<0.05),两两比较正常组与超重组、正常组与肥胖组差异均有统计学意义(P值均<0.05);男生中,不同BMI的肠道菌群宏基因组质量浓度差异无统计学意义(F=0.60,P>0.05)。结论内蒙古地区在校大学生BMI与其肠道菌群具有关联性,超重及肥胖人群肠道菌群宏基因组质量浓度显著降低。Objective To explore the correlation between BMI and gut microbiota of college students in Inner Mongolia,and to provide a reference basis for revealing the relationship between intestinal flora and obesity. Methods Totally 88 college students from Inner Mongolia Medical University were enrolled, Height and weight were measured,and the feces samples were collected. The bacterial metagenome was extracted from dry feces samples for the concentration detection in per gram of dry feces,expressed as μg/μL. Correlation between BMI and metagenomics concentration of gut microbiota was statistically analyzed. Meanwhile,the metagenomics concentration of gut microbiota in different BMI groups was compared with each other. Results There was a negative correlation between BMI and the metagenomics concentration of gut microbiota(r=-0.27,P<0.05). Significant difference in the concentration of gut microflora was observed between the normal group and the obesity group,the normal group and the overweight/obesity group(F=3.62,P<0.05). Among the female volunteers,there were significant differences between normal group and overweight group,between normal group and obesity group(F=1.87,P<0.05). No significant differences in metagenomics concentration of gut microbiota were found in different BMI groups(F=0.60, P>0.05) Conclusion There is a correlation between BMI and gut microbiota of college students in Inner Mongolia,the concentration of gut microflora metagenome in overweight and obese people decreased significantly.

关 键 词：人体质量指数 胃肠道 细菌 基因 学生 

分 类 号：R446[医药卫生—诊断学] R723.14[医药卫生—临床医学]