小儿肺咳颗粒联合特布他林治疗对支气管肺炎患儿肺功能、细胞免疫相关指标的影响  

Effect of Xiaoer Feike Granule Combined with Terbutaline on Pulmonary Function and Cellular Immune Indexes in Children with Bronchopneumonia

作　　者：刘淑琼[1] 刘金博[1] 阿丽亚•克力木 谢志军[1] 阿达来提•艾力 热依拉•阿布力克木 赛付丁•帕孜力 克地力亚•米吉提 LIU Shu-qiong;LIU Jin-bo;ALIYA•Kelimu;XIE Zhi-jun;ADALAITI•A ili;REYILA•Abulikemu;SAIFUDING•Pazili;KEDILIYA•Mijiti(Department of Pharmacy,the No.1 People’s Hospital of Kashgar Region,Kashi 844000,China)

机构地区：[1]喀什地区第一人民医院药学部,新疆喀什844000

出　　处：《药物生物技术》2020年第6期554-557,共4页Pharmaceutical Biotechnology

摘　　要：讨论小儿肺咳颗粒联合特布他林治疗对支气管肺炎患儿肺功能、细胞免疫相关指标的影响。选择该院儿科收治支气管肺炎患儿114例,按照治疗方式分成对照组(57例,常规治疗+雾化吸入硫酸特布他林雾化液)和观察组(57例,常规治疗+雾化吸入硫酸特布他林雾化液+小儿肺咳颗粒)。比较两组治疗前、后肺功能指标(PEF、FVC、FEV1)、细胞免疫相关指标(IL-10、IL-17、TGF-β1)及心肌酶指标(LDH、AST、CK、CK-MB以及α-HBDH)变化。治疗前,两组PEF,FVC,FEV1,IL-10,IL-17,TGF-β1,LDH,AST,CK,CK-MB andα-HBDH指标水平比较,差异均无统计学意义(P>0.05),治疗7 d后,两组患儿PEF、FVC、FEV1水平均较治疗前升高(P<0.05),观察组显著高于对照组(P<0.05),IL-10、IL-17、TGF-β1、LDH、AST、CK、CK-MB及α-HBDH水平均较治疗前降低(P<0.05),其中观察组PEF、FVC、FEV1水平高于对照组(P<0.05),IL-10、IL-17、TGF-β、LDH、AST、CK、CK-MB及α-HBDH水平均低于对照组(P<0.05)。小儿肺咳颗粒与特布他林联合治疗,能更有效改善支气管肺炎患儿肺功能,提高患儿机体细胞免疫功能,减轻免疫损伤,减轻心肌损伤。To discuss the effect of Xiaoer Feike Granule combined with terbutaline on pulmonary function and cellular immunity in children with bronchopneumonia,114 children with bronchopneumonia in the author’s hospital were selected and divided into control group(n = 57) and the observation group(n = 57),all the children received routine treatment such as infection control,cough relieving and phlegm resolving,continuous oxygen inhalation,antipyretic,electrolyte balance maintaining,acid poisoning correction,etc.In the control group was added aerosol inhalation of terbutaline sulfate aerosol on the basis of routine treatment,in the observation group was added aerosol inhalation of terbutaline sulfate aerosol and Xiaoer Feike Granule on the basis of routine treatment treatment.The changes of pulmonary function(PEF,FVC,FEV1),cellular immunity(IL-10,IL-17,TGF-β1) and myocardial enzymes(LDH,AST,CK,CK-MB and α-HBDH) were compared between the two groups before and after treatment.Before treatment,there was no significant difference in the level of indicators such as PEF,FVC,FEV1,IL-10,IL-17,TGF-β1,LDH,AST,CK,CK-MB and α-HBDH between the two groups(P>0.05).After 7 days of treatment,the levels of PEF,FVC and FEV1 in both groups were higher than those before treatment(P<0.05),while the levels of IL-10,IL-17,TGF-β1,LDH,AST,CK,CK-MB and α-HBDH were lower than those before treatment(P<0.05).The levels of PEF,FVC and FEV1 in the observation group were significantly higher than those in the control group(P<0.05),while the levels of IL-10,IL-17,TGF-β1,LDH,AST,CK,CK-MB and α-HBDH in the observation group were significantly lower than those in the control group(P<0.05).The combined treatment of Xiaoer Feike Granule and terbutaline can effectively improve the lung function of children with bronchopneumonia,improve the cellular immune function of children,alleviate the immune injury and reduce the myocardial injury.

关 键 词：小儿肺咳颗粒 特布他林 支气管肺炎 肺功能 细胞免疫 心肌酶指标 

分 类 号：R725[医药卫生—儿科] R56[医药卫生—临床医学]