Gold Nanostars-AIE Theranostic Nanodots with Enhanced Fluorescence and Photosensitization Towards Effective Image-Guided Photodynamic Therapy  

作　　者：Mohammad Tavakkoli Yaraki Min Wu Eshu Middha Wenbo Wu Soroosh Daqiqeh Rezaei Bin Liu Yen Nee Tan 

机构地区：[1]Institute of Materials Research and Engineering,Agency for Science,Technology and Research(A*STAR),Singapore 138634,Singapore [2]Department of Chemical and Biomolecular Engineering,National University of Singapore,4 Engineering Drive 4,Singapore 117585,Singapore [3]Department of Mechanical Engineering,National University of Singapore,9 Engineering Drive 1,Singapore 117575,Singapore [4]Faculty of Science,Agriculture and Engineering,Newcastle University,Newcastle Upon Tyne NE17RU,UK [5]Newcastle Research and Innovation Institute(NewRIIS),80 Jurong East Street 21,#05‑04,Singapore 609607,Singapore

出　　处：《Nano-Micro Letters》2021年第4期43-57,共15页纳微快报（英文版）

基　　金：supported by the Institute of Materials Research and Engineering under Biomimetic and Biomedical Materials program(IMRE/00-1P1400);Newcastle University(RSA/CCEAMD5010);National University of Singapore(R279-000-482-133);The funding from NRF Investigatorship(R279-000-444-281)is also appreciated。

摘　　要：Dual-functional aggregation-induced photosensitizers(AIE-PSs)with singlet oxygen generation(SOG)ability and bright fluorescence in aggregated state have received much attention in image-guided photodynamic therapy(PDT).However,designing an AIE-PS with both high SOG and intense fluorescence via molecular design is still challenging.In this work,we report a new nanohybrid consisting of gold nanostar(AuNS)and AIE-PS dots with enhanced fluorescence and photosensitization for theranostic applications.The spectral overlap between the extinction of AuNS and fluorescence emission of AIE-PS dots(665 nm)is carefully selected using five different AuNSs with distinct localized surface plasmon(LSPR)peaks.Results show that all the AuNS s can enhance the 1 O2 production of AIE-PS dots,among which the AuNS with LSPR peak at 585 nm exhibited the highest 1 O2 enhancement factor of15-fold with increased fluorescence brightness.To the best of our knowledge,this is the highest enhancement factor reported for the metalenhanced singlet oxygen generation systems.The Au585@AIE-PS nanodots were applied for simultaneous fluorescence imaging and photodynamic ablation of HeLa cancer cells with strongly enhanced PDT efficiency in vitro.This study provides a better understanding of the metal-enhanced AIE-PS nanohybrid systems,opening up new avenue towards advanced image-guided PDT with greatly improved efficacy.

关 键 词：Plasmon enhancement PHOTOSENSITIZER Aggregation-induced emission Fluorescence imaging THERANOSTICS 

分 类 号：O657.3[理学—分析化学] R730.5[理学—化学]