艾滋病儿童乙肝疫苗免疫效果及与CD4、CD8、HIV RNA的相关性研究  

Study on immune effect of hepatitis B vaccine in children with AIDS and its correlation with CD4,CD8 and HIV RNA

作　　者：鲁鸿燕[1] 梁富雄[1] 曾雪梅[1] 覃祺 Lu Hongyan;Liang Fuxiong;Zeng Xuemei;Tan Qi(Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention,Guangxi Nanning 530028)

机构地区：[1]广西壮族自治区疾病预防控制中心,广西南宁530028

出　　处：《中国社区医师》2021年第6期121-122,共2页Chinese Community Doctors

基　　金：广西卫生和计划生育委员会组织的自筹课题(合同号:Z20180982,课题名称:艾滋病儿童乙肝疫苗免疫效果研究)。

摘　　要：目的:探讨艾滋病儿童乙肝疫苗效果及与CD4、CD8、HIV RNA的相关性。方法:选取2018年1月-2020年1月行HARRT治疗的艾滋病儿童83例,所有患儿入院后均进行检查。对HBsAg<10 ng/mL(未感染HBV)且抗HBs水平<10 mIU/mL的患儿,按照0、1、6个方案接种乙肝疫苗;观察患儿乙肝疫苗接种效果,并分析艾滋病儿童乙肝疫苗免疫效果与CD4、CD8及HIV RNA的相关性。结果:83例患儿均全部完成0、1、6方案的乙肝疫苗接种。第3针注射完毕后,儿童抗-HBs阳性率高于第1针和第2针,差异有统计学意义(P<0.05);接种成功组第2、3针的CD4、CD8水平均高于接种失败组,差异有统计学意义(P<0.05);83例患儿乙肝疫苗注射后,接种成功76例(91.57%);相关性分析显示,艾滋病患儿乙肝疫苗免疫接种成功率与CD4、CD8水平呈正相关性。结论:艾滋病儿童乙肝疫苗免疫效果与CD4、CD8、HIV RNA水平密切相关,因此加强对CD4、CD8、HIV RNA水平的检测非常必要。Objective:To explore the efficacy of hepatitis B vaccine in children with AIDS and its correlation with CD4,CD8 and HIV RNA.Methods:From January 2018 to January 2020,83 children with AIDS who received HARRT were selected.All children were examined after hospitalization.Children with HBsAg<10 ng/mL(not infected with HBV)and anti-HBs levels<10 mIU/mL were vaccinated against hepatitis B in accordance with 0,1 and 6 programmes.To observe the effect of hepatitis B vaccine in children,and analyze the correlation between the immune effect of hepatitis B vaccine in children with AIDS and CD4,CD8 and HIV RNA.Results:All the 83 cases were inoculated with hepatitis B vaccine.After the third injection,the positive rate of anti-HBs in children was higher than the first and second injection,the difference was statistically significant(P<0.05).The CD4 and CD8 levels of the second and third injections in the successful inoculation group were higher than the failed inoculation group,the differences were statistically significant(P<0.05).After 83 cases of hepatitis B vaccination in children,76 cases(91.57%)were successfully vaccinated.Correlation analysis showed that the success rate of hepatitis B vaccine immunization was positively correlated with the levels of CD4 and CD8.Conclusion:The immune effect of hepatitis B vaccine in children with AIDS is closely related to the levels of CD4,CD8 and HIV RNA,so it is necessary to strengthen the detection of CD4,CD8 and HIV RNA levels.

关 键 词：艾滋病儿童 乙肝疫苗 HIV RNA 

分 类 号：R186[医药卫生—流行病学]