珠海市一起新型冠状病毒肺炎聚集性疫情流行病学调查  

Epidemiological investigation on a cluster epidemic of COVID-19 in Zhuhai City

作　　者：萧松建[1] 杨仁东 陈丹丹[1] 尹锡玲[1] 姚刚[1] 张雪宝[1] 林新天[1] 阮峰[1] 梅文华 XIAO Song-jian;YANG Ren-dong;CHEN Dan-dan;YIN Xi-ling;YAO Gang;ZHANG Xue-bao;LIN Xin-tian;RUAN Feng;MEI Wen-hua(Zhuhai Municipal Center for Disease Control and Prevention,Zhuhai,Guangdong 519000,China)

机构地区：[1]珠海市疾病预防控制中心,广东珠海519000

出　　处：《实用预防医学》2021年第2期135-139,共5页Practical Preventive Medicine

基　　金：珠海市科技创新局课题(ZH22036302200077PWC,珠海市新型冠状病毒性肺炎流行病学及防控策略研究)。

摘　　要：目的对珠海市一起新型冠状病毒肺炎(简称新冠肺炎,COVID-19)聚集性疫情进行流行病学调查分析,为防控策略提供依据。方法采用现场流行病学方法对该起疫情7例病例、3例无症状感染者及密切接触者进行调查,描述分析流行病学特征以及传播链;实时荧光RT-PCR方法检测新型冠状病毒(SARS-CoV-2)核酸。结果余某家族4个家庭18人,2020年1月16-21日从武汉分批到珠海并入住GLHT等酒店,1月24日年夜饭聚餐。病例1于1月27日发病,2月12日发现并确诊。2月12-28日17名密切接触者集中隔离期间相继有7名人员SARS-CoV-2核酸筛查阳性;解除隔离后第7 d(3月5日)又有2名人员筛查阳性,为无症状感染者。本次疫情共7例病例、3例无症状感染者,传播链分析可能有4代感染者,暴露时间均为集中隔离前。结论 COVID-19发病前3 d具有传染性,密切接触者暴露后SARS-CoV-2核酸转阳最长时间≥15 d,14 d隔离期不足以排除所有感染者。Objective An epidemiological investigation and analysis was conducted on a cluster epidemic of COVID-19 in Zhuhai City so as to provide a basis for prevention and control strategies. Methods Field epidemiological methods were applied to surveying 7 cases, 3 cases of asymptomatic infection and their close contacts. Their epidemiological characteristics and transmission chains were described and analyzed. Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) nucleic acid was detected by real-time fluorescence reverse transcriptase polymerase chain-reaction. Results From January 16 to 21 in 2020, 18 members from 4 families of Yu family arrived in batches in Zhuhai from Wuhan and lived in GLHT hotel. They had a dinner party on the New Year’s eve on January 24. The onset of the first case was on January 27, but the case was detected and confirmed on February 12. From February 12 to 28, 7 of 17 close contacts were tested positive for SARS-CoV-2 nucleic acid during the concentrated quarantine period. On the seventh day after the quarantine( March 5),another two persons were detected positive,and both of them were asymptomatic infected patients. A total of 7 cases and 3 asymptomatic infected patients were found in this epidemic. Analysis of transmission chains showed 4 generations of infection,and their exposure time was before the concentrated quarantine. Conclusions COVID-19 is infectious 3 days before the onset of symptoms. The longest time for positive conversion of SARS-Co V-2 nucleic acid in close contacts after the exposure was ≥ 15 days,and the 14-day quarantine period is not enough to exclude all infected persons.

关 键 词：新型冠状病毒肺炎 聚集性疫情 流行病学 调查 

分 类 号：R563.14[医药卫生—呼吸系统]