社区老年人血尿酸水平与其他代谢指标的相关性分析  

Correlation between serum uric acid level and other metabolic indicators in the community elderly

作　　者：龙静铧 孙雯[1] 梁艺王莹 梁杏欢[1] 梁友芳[1] LONG Jing-hua;SUN Wen;LIANG Yi-ying;LIANG Xing-huan;LIANG You-fang(The First Affiliated Hospital of Guangxi Medical University,Nanning,Guangxi 530021,China)

机构地区：[1]广西医科大学第一附属医院,广西南宁530021

出　　处：《实用预防医学》2021年第2期171-174,共4页Practical Preventive Medicine

基　　金：2018年广西壮族自治区卫生和计划生育委员会自筹经费项目“公立医院承办社区医护团队合作对慢性病管理模式的探讨”(Z20180898);国家卫生计生委卫生发展研究中心委托课题,国家卫生计生委“整合型医疗卫生服务体系的理论和实现途径研究”(卫计委支撑项目18009)。

摘　　要：目的探讨老年人血尿酸(serum uric acid,SUA)水平与其他代谢指标的相关性。方法选取2017年1-12月某社区体检的老年人为研究对象,测量身高、体重,测定SUA、SBP、DBP、总胆固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)、高密度脂蛋白胆固醇(high-density lipoprotein cholesterol,HDL-C)、低密度脂蛋白胆固醇(low-density lipoprotein cholesterol,LDL-C)、糖化血红蛋白(glycated hemoglobin,HbA1c)、空腹血糖(fasting blood glucose,FBG)水平,分析SUA水平与其他代谢指标的关系。结果高尿酸血症(hyperuricemia,HUA)患病率为17.74%。男性老年人HUA患病率高于女性,其HUA组体质指数(body mass index,BMI)和TG,女性老年人HUA组年龄、BMI、SBP、TG、HbA1c、FBG均高于尿酸正常(normal uric acid, NUA)组,男女性老年人HUA组HDL-C低于NUA组。男性老年人群SUA水平与TC、TG、LDL-C、SBP、DBP、FBG及BMI呈正相关而与HDL-C呈负相关。女性老年人群SUA水平与TG、FBG、SBP及BMI呈正相关而与HDL-C呈负相关。非条件logistic回归结果显示,BMI、TG、HDL-C和年龄是男性老年人SUA水平的影响因素,BMI、TG和年龄是女性老年人SUA水平的影响因素。结论应采取综合干预措施预防HUA的发生,定期体检发现尿酸水平异常并及时制定相应的防治措施。Objective To explore the correlation of serum uric acid(SUA) level with other metabolic indicators in the elderly. Methods The elderly who received physical check-up in a community from January to December, 2017 were selected as the research subjects. We measured their height and weight, SUA, systolic blood pressure(SBP), diastolic blood pressure(DBP), total cholesterol(TC), triglyceride(TG), high-density lipoprotein cholesterol(HDL-C), low-density lipoprotein cholesterol(LDL-C), glycated hemoglobin(HbA1 c) and fasting blood glucose(FBG) levels, and then analyzed the association between SUA level and other metabolic indicators. Results The prevalence rate of hyperuricemia(HUA) was 17.74%. The prevalence rate of HUA was higher in the male elderly than in the female elderly. Body mass index(BMI) and TG of the male elderly with HUA and age, BMI, SBP, TG, HbA1 c and FBG of the female elderly with HUA were all higher than those of the normal uric acid(NUA) group. HDL-C was lower in the male and female elderly with HUA than in the NUA group. SUA level of the male elderly was positively correlated with TC, TG, LDL-C, SBP, DBP, FBG and BIM, but negatively correlated with HDL-C. SUA level of the female elderly was positively correlated with TG, FBG, SBP and BMI, but negatively correlated with HDL-C. Unconditional logistic regression analysis showed that BMI, TG, HDL-C and age were factors influencing SUA level of the male elderly, while BMI, TG and age were factors influencing SUA level of the female elderly. Conclusions Comprehensive intervention measures should be taken to prevent the occurrence of HUA. Corresponding prevention and treatment measures should be developed in time when UA level is found to be abnormal in regular physical examination.

关 键 词：尿酸 高密度脂蛋白胆固醇 体质指数 老年人 

分 类 号：R161.7[医药卫生—公共卫生与预防医学]