补肾活血通络法应用于薄型子宫内膜患者冻融胚胎移植激素替代周期内膜准备中的临床研究  

Bushen-Huoxue-Tongluo regimen for endometrial preparation during hormone replacement cycle in patients with thin endometrium undergoing frozen-thawed embryo transfer:a clinical study

作　　者：钟冬梅[1] 李斯晨[1] 黎青[1] 冯崇廉[1] 陈文裕[1] 罗美婷[1] 袁露 Zhong Dongmei;Li Sichen;Li Qing;Feng Chonglian;Chen Wenyu;Luo Meiting;Yuan Lu(Department of Chinese Traditional Medicine,Third Affiliated Hospital,Guangzhou Medical University,Guangzhou 510175,China)

机构地区：[1]广州医科大学附属第三医院中医科,广州510175

出　　处：《中华生物医学工程杂志》2020年第5期458-463,共6页Chinese Journal of Biomedical Engineering

基　　金：广东省中医药局科研项目(20181161)。

摘　　要：目的研究补肾活血通络法在薄型子宫内膜患者冻融胚胎移植激素替代周期内膜准备中的作用。方法以100例行冻融胚胎移植(FET)周期内膜准备中薄型子宫内膜不孕患者作为研究对象,随机分为治疗组和对照组各50例,两组均采用口服戊酸雌二醇片激素替代疗法,治疗组联合中医补肾活血通络法治疗,对照组联合口服阿司匹林治疗,记录两组治疗前后子宫内膜厚度、形态(A型子宫内膜)和雌激素水平以及周期取消率,观察治疗前后各组治疗方法对薄型子宫内膜患者的干预作用。结果治疗组治疗后比治疗前子宫内膜厚度增厚,A型子宫内膜增多、雌激素E2水平升高(P<0.05),对照组治疗后比治疗前子宫内膜厚度增厚(P<0.05)。但A型子宫内膜、雌激素E2水平变化无统计学意义(P>0.05)。两组治疗后治疗组子宫内膜增厚、A型子宫内膜数量、雌激素E2水平增高优于对照组,周期取消率少于对照组(P<0.05)。补肾活血通络法能改善薄型子宫内膜患者冻融胚胎移植激素替代周期内膜准备中的子宫内膜厚度、A型子宫内膜和提高雌激素E2水平。结论补肾活血通络法可作为薄型子宫内膜患者FET周期中西医结合内膜准备方案的一种新方法。Objective To investigate the effect of Bushen-Huoxue-Tongluo(BHT)regimen for endometrial preparation during hormone replacement cycle(HRC)in patients with thin endometrium undergoing frozen-thawed embryo transfer(FET).Methods Included in this study were 100 patients with thin endometrium-associated infertility during their HRC prior to FET.The subjects were randomly divided into the treatment group and control group(n=50 each).The both groups received hormone replacement therapy with oral estradiol valerate tablets.In addition,the treatment group was given traditional Chinese medicine with BHT regimen,and the control group was given oral aspirin.The endometrial thickness,type-A morphology of endometrium,estrogen level and cycle cancellation rate were recorded before and after treatment in the two groups.The interventional outcome of treatments in patients with thin endometrium were investigated.Results After treatment,the treatment group showed increases in endometrial thickness,proportion of type-A morphology of endometrium,and the level of estrogen E2(all P<0.05)compared with baseline;while the endometrial thickness was increased in the control group(P<0.05),there were no statistically significant changes in A-type morphology of endometrium and estrogen E2 level(P>0.05)compared with baseline.After treatment,the treatment group showed thicker endometrium,more patients with type A endometrium,higher estrogen E2 level,and lower cycle cancellation rate than did the control group(P<0.05).The BHT regimen was associated with improvements in endometrial thickness,type A endometrium morphology and estrogen E2 level for endometrial preparation during HRC in patients with thin endometrium undergoing FET.Conclusion Bushen-Huoxue-Tongluo regimen can be used as a novel option for endometrial preparation during HRC for patients with thin endometrium undergoing FET.

关 键 词：子宫内膜 胚胎移植 补肾 

分 类 号：R714.8[医药卫生—妇产科学]