亚临床甲状腺功能减退症对习惯性流产史患者再次妊娠结局的影响分析  

Analysis on the impacts of subclinical hypothyroidism on the outcome of re-pregnancy in patients with recurrent pregnancy loss history

作　　者：张丽 胡新欣 ZHANG Li;HU Xinxin(Department of Clinical Laboratory,Shenzhen Pingshan Maternal and Child Health Care Hospital,Guangdong,Shenzhen 518122,China)

机构地区：[1]深圳市坪山区妇幼保健院检验科,广东深圳518122

出　　处：《中国医药科学》2021年第1期186-188,199,共4页China Medicine And Pharmacy

基　　金：广东省深圳市坪山区卫生系统科研资助项目(201735)。

摘　　要：目的分析习惯性流产(RPL)患者亚临床甲状腺功能减退症(SCH)患病率及再次妊娠结局。方法对2018年1月至2019年12月于深圳市坪山区妇幼保健院就诊的726例RPL患者进行跟踪分析,收集其年龄、流产次数、复发性流产原因等一般信息,排除前期经确诊涉及RPL常见原因(血栓因素、子宫异常等)的患者,其余患者均接受甲状腺激素检查;统计RPL患者SCH患病率并分析甲状腺功能正常患者和SCH患者妊娠结局。结果二次筛选后的456例患者中,SCH组(78例,17.11%)、甲状腺功能正常组(337例,73.90%)患者年龄、流产次数、体重指数(BMI)、再次妊娠人数比较,差异无统计学意义(P>0.05);215例再次妊娠患者均为单胎妊娠,且SCH组再次妊娠患者自然流产、胎儿宫内生长受限、胎盘早剥、新生儿呼吸窘迫综合征出现率、低体重儿出生率远高于甲状腺功能正常组,足月分娩出现率远低于甲状腺功能正常组,差异有统计学意义(P<0.05)。结论SCH可增加习惯性流产患者再次妊娠不良结局发生率。Objective To analyze the prevalence of subclinical hypothyroidism(SCH)and the outcome of repregnancy in patients with recurrent pregnancy loss(RPL).Methods A total of 726 patients with RPL admitted to Shenzhen Pingshan Maternal and Child Health Care Hospital from January 2018 to December 2019 were followed up and analyzed,and general data such as age,abortion times and causes of recurrent abortion were collected.The patients who were diagnosed as related to the common causes of RPL(thrombotic factors,uterine abnormalities,etc.)were excluded,and the rest patients were examined for thyroid hormone.The prevalence of subclinical hypothyroidism(SCH)in patients with RPL was analyzed,and the pregnancy outcomes of patients with normal thyroid function and patients with SCH were analyzed.Results Among 456 patients after the second screening,there were 78 cases(17.11%)in the SCH group and 337 cases(73.90%)in the normal thyroid function group.There were no statistically significant differences in age,abortion times,BMI and number of re-pregnancies(P>0.05).215 cases of repregnancy were single pregnancy,and the incidence of spontaneous abortion,intrauterine growth restriction,placental abruption,neonatal respiratory distress syndrome and birth rate of low birth weight infants in the SCH group were significantly higher than those in the normal thyroid function group,the incidence of full-term delivery was much lower than that in the normal thyroid function group,and the differences were statistically significant(P<0.05).Conclusion Subclinical hypothyroidism can increase the incidence of adverse pregnancy outcomes in patients with RPL.

关 键 词：亚临床甲状腺功能减退症 习惯性流产 妊娠结局 异质性疾病 

分 类 号：R714.256[医药卫生—妇产科学]