维生素D与自身免疫性甲状腺疾病研究进展  

Research progress of vitamin D and autoimmune thyroid diseases

作　　者：李心爱 祁烁[2] 李哲[2] 张磊 丁治国[2] 杨亚鹏[2] LI Xin'ai;QI Shuo;LI Zhe;ZHANG Lei;DINGZhiguo;YANG Yapeng(The First Clinical College of Beijing University of Traditional Chinese Medicine,Beijing 100029,China;Department of Thyroid Diseases,Dongzhimen Hospital of Beijing University of Traditional Chinese Medicine,Beijing 100700,China)

机构地区：[1]北京中医药大学第一临床医学院,北京100029 [2]北京中医药大学东直门医院甲状腺病科,北京100700

出　　处：《中国医药科学》2021年第2期40-42,46,共4页China Medicine And Pharmacy

基　　金：北京中医药大学青年教师项目(2019-JYB-JS-057);北京中医药新奥奖励基金项目(2019-XAJLJJ-011)。

摘　　要：维生素D是一种脂溶性维生素,是固醇类衍生物。在过去人们经常了解到其在骨骼肌系统和钙/磷稳态中发挥着主要的作用,近年来,各国学者对维生素D及其受体在自身免疫性甲状腺疾病(AITD)发病中的作用进行了广泛的研究。本文通过检索2010—2019年Web of science、PubMed、Cochrane和中国知网等数据库关于维生素D及维生素受体在甲状腺疾病中的相关出版物,旨在阐述维生素D在AITD中可能的作用。结果表明,补充维生素D在AITD的治疗过程中有协助作用,然而其相关作用机制并未完全明确,维生素D在自身免疫性甲状腺疾病中治疗的有效性及安全性仍需要后续相关研究来明确。Vitamin D is a fat-soluble sterol derivative.In the past,VD is often known to play a major role in skeletal muscle system and calcium/phosphorus homeostasis.In recent years,extensive studies have been conducted by scholars worldwide on the role of VD and its receptors in the pathogenesis of autoimmune thyroid disease(AITD).The purpose of this paper is to explore the possible role of VD in AITD by searching the relevant publications of VD and its receptors in thyroid diseases in Web of science,PubMed,Cochrane and China National Knowledge Internet from 2010 to 2019.It was indicated that VD supplementation can help to treat AITD,but its mechanism remains unclear.The efficacy and safety of VD in the treatment of AITD still ne ed to be confirmed by follow-up studies.

关 键 词：自身免疫性甲状腺疾病 桥本甲状腺炎 维生素D 维生素D受体 

分 类 号：R581[医药卫生—内分泌]