肥胖诱发哮喘发病的作用机制研究进展  

Research progress on the mechanism of obesity-induced asthma

作　　者：徐洋海 刘甡[1] 刘雪凤 XU Yanghai;LIU Shen;LIU Xuefeng(Department of Respiratory Medicine,the First Affiliated Hospital of Jiamusi University,Heilongjiang,Jiamusi 154000,China)

机构地区：[1]佳木斯大学附属第一医院呼吸内科,黑龙江佳木斯154000

出　　处：《中国医药科学》2021年第2期50-53,共4页China Medicine And Pharmacy

摘　　要：近年来,随着生活水平的提高,肥胖症的发病率迅速增高,由此导致的系统性疾病也逐渐增多,如合并肥胖的支气管哮喘,其发病率逐年增高,症状控制情况也不甚理想。肥胖患者因气道环境改变及体液中多种细胞因子(尤其是瘦素、脂联素及抵抗素)浓度变化,不仅导致其哮喘发病风险上升,而且哮喘控制情况更差。本文就国内外关于肥胖症诱发哮喘发病的作用机制作一综述。In recent years,with the development of people's living standards,the incidence of obesity has increased rapidly.It results in a gradual increase in systemic diseases,such as bronchial asthma complicated with obesity,the incidence of which has increased year by year.Meanwhile,the symptom control situation is not satisfying.Due to the changes of airway environment and cytokines(especially leptin,adiponectin and resistin)in body fluid,obese people have not only an increasing risk of asthma,but also bad asthma control.The mechanism of obesity-induced asthma at home and abroad was reviewed in this paper.

关 键 词：肥胖症 支气管哮喘 作用机制 研究进展 

分 类 号：R589.2[医药卫生—内分泌] R562.25[医药卫生—内科学]