Warburg效应与动脉型肺动脉高压的研究进展  

Research progress in Warburg effect and pulmonary arterial hypertension

作　　者：杨逸成 肖志强 陈罗雅凯 刘旭玲[4] 赵卫[4] 何小艳[3] YANG Yi-cheng;XIAO Zhi-qiang;CHEN-LUO Ya-kai;LIU Xu-ling;ZHAO Wei;HE Xiao-yan(State Key Laboratory of Cardiovascular Disease,Fuwai Hospital,National Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100037,China;Department of Clinical Medi-cine,Zhengzhou University,Zhengzhou 450001,China;The First Clinical Department,Southern Medical University,Guangzhou 510515,China;School of Public Health,Southern Medical University,Guangzhou 510515,China)

机构地区：[1]中国医学科学院北京协和医学院阜外医院肺血管病中心,北京100037 [2]郑州大学医学院临床医学系,河南郑州450001 [3]南方医科大学第一临床医学院,广东广州510515 [4]南方医科大学公共卫生学院,广东广州510515

出　　处：《中国病理生理杂志》2021年第2期375-378,共4页Chinese Journal of Pathophysiology

基　　金：国家重点研发计划(No.2018YFC1602206);广东省科技攻关项目(No.2019A141405015);广州市科技攻关项目(No.201803040006);阳江市科技攻关项目(No.2019010)。

摘　　要：肺动脉高压(pulmonary hypertension)是一种进展性疾病,病理生理学机制复杂多样^([1]),其血管特征在于内皮功能障碍、内膜增生、原位血栓形成、炎性细胞浸润以及广泛肺血管重塑^([2-5])。有氧糖酵解又称Warburg效应,是导致动脉型肺动脉高压(pulmonary arterial hypertension,PAH)发生发展的重要机制之一^([6-8])。目前研究指出肺动脉内皮细胞(pulmonary artery endothelial cell,PAEC)、肺动脉平滑肌细胞(pulmonary artery smooth muscle cell,PASMC)、肺血管成纤维细胞及右心室心肌细胞等发生的Warburg效应均在PAH的发生发展中发挥重要的调控作用,但其相关分子机制并不完全一致。The Warburg effect in pulmonary vascular endothelial cells,pulmonary vascular smooth muscle cells,pulmonary fibroblasts,right ventricular cells and so on plays an important regulatory role in the occurrence and development of pulmonary arterial hypertension(PAH).Studies have shown that up-regulation of hypoxia-inducible factor,dysfunction of mitochondrial calcium uniporter,high expression of endothelin-1 and regulation of key enzymes in glucose metabolism are related to the occurrence of the Warburg effect.This review summarizes the mechanisms of the Warburg effect in different types of cells for deeply understanding the pathogenesis of PAH.

关 键 词：动脉型肺动脉高压 代谢重编辑 线粒体 Warburg效应 

分 类 号：R543.2[医药卫生—心血管疾病] R363[医药卫生—内科学]