NaYF4:Nd^(3+),Yb^(3+)纳米粒子用于生物体系温度测量  

NaYF_(4):Nd^(3+), Yb^(3+) Nanocrystals for Temperature Measurement in Biological Environment

作　　者：徐心成 顾昱飏 孔梦涯 冯玮 李富友[1] Xu Xincheng;Gu Yuyang;Kong Mengya;Feng Wei;Li Fuyou(Department of Chemistry,Fudan University,Shanghai 200438,China)

机构地区：[1]复旦大学化学系,上海200438

出　　处：《中国稀土学报》2021年第1期181-187,共7页Journal of the Chinese Society of Rare Earths

基　　金：国家自然科学基金项目(21722101)资助。

摘　　要：采用溶剂热法制备了Nd^(3+)敏化Yb^(3+)的近红外纳米探针NaYF_(4):Nd^(3+),Yb^(3+),观察到材料在980与865 nm两处发光峰的强度比值随温度的升高而降低。通过对探针中Nd^(3+)/Yb^(3+)比例的调节,综合考虑材料的发光强度与温敏效率,确定了NaYF4:2%Nd, 20%Yb为所测条件下适用于测量生物体系温度的较优组成。材料转水相前后温敏效率均随着Yb^(3+)离子掺杂增加而提高,环己烷中最高可达1.9%·K^(-1),水相中最高为0.46%·K^(-1)。通过盖肉片模拟及激光加热活体成像实验,研究了温敏材料在生物环境中发光随温度的变化情况,以及组织遮挡前后荧光比值未发生明显变化的结果,初步验证了使用该探针测量生物体系温度的可行性。Nd^(3+)-sensitized NIR-emissive NaYF_(4): Nd^(3+), Yb^(3+) nanocrystals were synthesized by solvothermal method. A decrease in the intensity ratio of 865 nm/980 nm peak was observed as temperature increased tuning the Nd^(3+) and Yb^(3+) doping ratio, and comprehensively considering the luminescent intensity and temperature sensitivity, 2% Nd and 20% Yb were found to be the optimal doping concentration. The thermal sensitivity can be increased with Yb^(3+) doping ratio, with a thermal sensitivity(Sr) of 1.9%·K^(-1) in cyclohexane and 0.46%·K^(-1) in aqueous phase. Through the demonstrations of covering meat slices and in vivo laser heating, no obvious change in the intensity ratio was found before and after tissue attenuation, which preliminarily verified the feasibility of using the nanothermometer for measuring temperature in biological systems.

关 键 词：稀土纳米晶 温度探针 活体成像 

分 类 号：O614.33[理学—无机化学]