射频四极杆离子导向用于质子转移反应飞行时间质谱的传输特性研究  

Study on Transmission Characteristics of Radio Frequency Quadrupole Ion Guide for Proton Transfer Reaction Time-of-Flight Mass Spectrometry

作　　者：贺飞耀 刘泽平 代渐雄 李雯雯 郭星 付玉 岳寒露 李宏[1] 邓辅龙 赵忠俊[6] 段忆翔[1,7] HE Fei-Yao;LIU Ze-Ping;DAI Jian-Xiong;LI Wen-Wen;GUO Xing;FU Yu;YUE Han-Lu;LI Hong;DENG Fu-Long;ZHAO Zhong-Jun;DUAN Yi-Xiang(College of Life Science,Sichuan University,Chengdu 610064,China;China Nuclear Xiapu Nuclear Power Co.,Ltd,Ningde 355100,China;College of Chemistry and Materials Science,Northwest University,Xi′an 710127,China;West China School of Public Health,Sichuan University,Chengdu 610064,China;School of Mechanical Engineering,Sichuan University,Chengdu 610064,China;School of Chemical Engineering,Sichuan University,Chengdu 610064,China;Aliben Science&Technology CO.,LTD,Chengdu 610064,China)

机构地区：[1]四川大学生命科学学院,成都610064 [2]中核霞浦核电有限公司,宁德355100 [3]西北大学化学与材料科学学院,西安710127 [4]四川大学华西公共卫生学院,成都610064 [5]四川大学机械工程学院,成都610064 [6]四川大学化学工程学院,成都610064 [7]成都艾立本科技有限公司,成都610064

出　　处：《分析化学》2021年第3期359-365,共7页Chinese Journal of Analytical Chemistry

基　　金：四川省重大科学仪器设备专项项目(No.2019ZDZX0036)资助。

摘　　要：射频四极杆离子导向器(RF-QIG)具有结构简单、传输效率高等优点,被广泛应用于各类质谱系统中。本研究将自主研制的RF-QIG集成于质子转移反应飞行时间质谱(PTR-TOF MS),考察了此装置在不同工作频率及电压幅值下对不同质荷比(m/z)离子的传输特性。结果表明,此RF-QIG在频率低于1 MHz时,无法传输m/z<40的离子,而H_(3)O^(+)(m/z 19)和H_(2)O·H_(3)O^(+)(m/z 37)在2.48和3.43 MHz频率下获得了非常强的质谱信号。此外,对于较高质量数的离子,如[C_(3)H_(6)O+H]^(+)(m/z 59)、[C_(6)H_(6)+H]^(+)(m/z 79)和[C_(7)H_(8)+H]^(+)(m/z 93),均在2.48 MHz获得最强信号。MATLAB对有效电势的求解结果表明,电压幅值不变时,频率越高,有效电势越低。采用PTR-QIG-TOF MS对实验室背景空气进行了检测,效果良好,表明RF-QIG可满足实际应用需求。Radio frequency quadrupole ion guide(RF-QIG)is widely used in various mass spectrometry systems because of its simple structure and high transmission efficiency.In this study,the self-developed RF-QIG was successfully integrated into the proton transfer reaction time-of-flight mass spectrometry(PTR-TOF MS).Through the adjustment of variable radio frequency electric field,the transmission characteristics of the device in ions with different mass-charge ratio(m/z)at different operating frequencies and voltage amplitudes were investigated.The results showed that when the frequency was less than 1 MHz,the RF-QIG reported here couldn′t transport ions with m/z less than 40,while H_(3)O^(+)(m/z 19)and H_(2)O·H_(3)O^(+)(m/z 37)could obtain strong MS signals at 2.48 MHz and 3.43 MHz.In addition,for the ions with higher m/z,such as[C 3 H_(6)O+H]^(+)(m/z 59),[C_(6)H_(6)+H]^(+)(m/z 79)and[C_(7)H_(8)+H]^(+)(m/z 93),the strongest signals were all obtained at 2.48 MHz.The results of MATLAB′s numerical solution of the effective potential showed that when the voltage amplitude was constant,the higher the frequency was given,the lower the effective potential was obtained.Finally,the successful detection of the background air in the laboratory showed that RF-QIG could be used in the ion transportation of PTR-TOF MS system.

关 键 词：离子导向 射频四极杆 质子转移反应质谱 飞行时间质谱 

分 类 号：O657.63[理学—分析化学]