帕金森病与血清尿酸、同型半胱氨酸水平的相关性研究  

Correlation between serum uric acid and homocysteine levels in Parkinson’s disease

作　　者：王台 史长河[1] 毛澄源[1] 张书语 范丽媛 范雨 郑惠敏[1] 杨靖[1] 张槊 胡正威[1] 许予明[1] WANG Tai;SHI Changhe;MAO Chengyuan(Department of Neurology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学第一附属医院神经内科,河南郑州450052

出　　处：《中风与神经疾病杂志》2021年第2期117-121,共5页Journal of Apoplexy and Nervous Diseases

基　　金：中国国家重点研发计划(2017YFA0105000);国家自然科学基金(81530037);国家自然科学基金(91849115);国家自然科学基金(81771290);国家自然科学基金(81974211);国家自然科学基金(81901300)。

摘　　要：目的探讨帕金森病(Parkinson’s disease,PD)与血清尿酸(Uric acid,UA)、同型半胱氨酸(Homocysteine,HCY)水平的相关性,以及血清UA、HCY水平与PD是否合并认知障碍、不同的临床亚型、病情分期之间的关系。方法前瞻性连续纳入PD患者114例,正常对照123例,详细收集其基线资料,对PD进行H-Y分期、MDS-UPDRS量表、MMSE量表评估并分组,测定其血清UA、HCY水平并对结果进行分析比较。结果PD组血清UA水平明显低于对照组[(241.2±60.8)μmol/L vs(271.2±55.7)μmol/L,P<0.05],血清HCY水平明显高于对照组[(16.11±6.01)μmol/L vs(12.41±2.94)μmol/L,P<0.05];在PD组内,伴认知障碍组血清UA水平明显低于不伴认知障碍组[(22457.94)μmol/L vs(248.560.96)μmol/L,P<0.05],而不同临床亚型、不同病情分期间血清UA、HCY水平无明显差异。结论与对照组相比,PD组血清UA水平明显下降,血清HCY水平明显升高,在PD组内,伴认知障碍组血清UA水平明显低于不伴认知障碍组。Objective To investigate the correlation between serum uric acid and homocysteine levels in Parkinson’s disease(PD),as well as the relationship between serum uric acid and homocysteine levels with cognitive impairment,clinical subtypes,different disease stages in PD.Methods One hundred and fourteen patients with Parkinson’s disease and 123 healthy controls were included.Detailed baseline data were collected and patients with Parkinson’s disease were evaluated and grouped by Hoehn and Yahr、MDS-UPDRS and MMSE scale.Serum uric acid and homocysteine levels were measured and compared in all subjects.Results The serum uric acid level of PD group was significantly lower than that of the control group[(241.2±60.8)μmol/L vs(271.2±55.7)μmol/L,P<0.05].The serum homocysteine level of PD group was significantly higher than that of the control group[(16.11±6.01)μmol/L vs(12.41±2.94)μmol/L,P<0.05].In PD group,serum uric acid level of patients with cognitive impairment was significantly lower than that of patients without cognitive impairment[(22457.94)μmol/L vs(248.560.96)μmol/L,P<0.05],and there was no statistically significant difference between clinical subtypes and different disease stages in PD.Conclusion Compared with the normal control group,serum uric acid level was significantly decreased in PD group,serum homocysteine level was significantly increased in PD group.In PD group,serum uric acid level was significantly lower in patients with cognitive impairment.

关 键 词：帕金森病 尿酸 同型半胱氨酸 认知障碍 

分 类 号：R742.5[医药卫生—神经病学与精神病学]