HIF-1α在病理性瘢痕中的作用研究  

Study on the Role of HIF-1αin Pathological Scars

作　　者：蔡润智 谢有富[1] 何飘飘 魏文龙 张益勋 CAI Run-zhi;XIE You-fu;HE Piao-piao;WEI Wen-long;ZHANG Yi-xun(Department of Burns and Plastic Surgery,Guangzhou Red Cross Hospital,Jinan University,Guangzhou 510235,Guangdong,China)

机构地区：[1]暨南大学附属广州红十字会医院烧伤整形科,广东广州510235

出　　处：《医学信息》2021年第4期57-59,63,共4页Journal of Medical Information

摘　　要：病理性瘢痕指是发生在各种外伤创面愈合后,由于创面过度修复引起的以大量胶原纤维沉积与细胞外基质过量产生为特征的一种皮肤纤维增生性疾病,包括增生性瘢痕和瘢痕疙瘩等。目前,关于病理性瘢痕的发病机制尚未完全清楚,对此类疾病仍缺乏满意的防治手段。大量研究显示,缺氧诱导因子1-α(HIF-1α)在病理性瘢痕发生发展过程中起着不容忽视的作用。为此,本文主要就HIF-1α在病理性瘢痕形成过程中的作用进行综述,旨在为临床治疗该病提供新的思路。Pathological scar refers to a skin fibroproliferative disease characterized by a large amount of collagen fiber deposition and excessive production of extracellular matrix caused by excessive repair of the wound after healing of various traumatic wounds,including hypertrophic scars and keloids,etc.At present,the pathogenesis of pathological scars is not yet fully understood,and there is still a lack of satisfactory prevention and treatment methods for such diseases.A large number of studies have shown that hypoxia-inducible factor 1-α(HIF-1α)plays an important role in the development of pathological scars.To this end,this article mainly reviews the role of HIF-1αin the process of pathological scar formation,aiming to provide new ideas for clinical treatment of the disease.

关 键 词：病理性瘢痕 缺氧诱导因子1-Α 胶原纤维 增生性瘢痕 瘢痕疙瘩 

分 类 号：R622[医药卫生—整形外科]