阻塞性睡眠呼吸暂停低通气综合征患者病情严重程度与血液学指标的相关性分析  

Correlation Analysis Between the Severity of Illness and Hematological Indexes in Patients with Obstructive Sleep Apnea Hypopnea Syndrome

作　　者：高俊康 万玉峰[1] GAO Jun-kang;WAN Yu-feng(Department of Otorhinolaryngology Head and Neck Surgery,Chaohu HospitalAffiliated to Anhui Medical University,Hefei 238000,Anhui,China)

机构地区：[1]安徽医科大学附属巢湖医院耳鼻喉头颈外科,安徽合肥238000

出　　处：《医学信息》2021年第4期84-87,91,共5页Journal of Medical Information

基　　金：2019年度安徽省高校自然科学基金项目(编号:KJ2019A0260)。

摘　　要：目的探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者的病情严重程度与血液学指标的相关性。方法回顾性分析2017年1月~2019年12月就诊于安徽医科大学附属巢湖医院耳鼻喉头颈外科的147例OSAHS患者的临床资料,并将其设置为病例组,应用多导睡眠检测法(PSG)记录患者睡眠相关参数,根据睡眠呼吸暂停低通气指数(AHI)将病例组分为轻度、中度、重度三组,另选取50名本院健康体检者设为对照组,比较各组血液学指标[中性粒细胞计数(NEUT)、淋巴细胞计数(LY)、血小板计数(PLT)、血小板分布宽度(PDW)、平均血小板体积(MPV)、中性粒细胞/淋巴细胞比值(NLR),血小板/淋巴细胞比值(PLR)]、睡眠呼吸暂停低通气指数(AHI)及最低血氧饱和度(LSaO_(2))。结果各组MPV、PDW、NLR、AHI、LSaO_(2)、比较,差异均有统计学意义(P<0.05),其中AHI、MPV、PDW、NLR:重度组>中度组>轻度组>对照组;LSaO2:重度组<中度组<轻度组<对照组;各组PLR比较,差异无统计学意义(P>0.05)。Pearson相关分析显示,AHI与MPV、PDW及NLR均呈正相关(r=0.479、0.772、0.629,P<0.05)。结论MPV、PDW、NLR对OSAHS患者的病情严重程度判断有重要价值,血液学指标检测经济简便易行可用于临床对OSAHS病情轻重的初步评估。Objective To explore the relationship between the severity of the disease and the hematological parameters in patients with obstructive sleep apnea hypopnea syndrome(OSAHS).Methods A retrospective analysis of the clinical data of 147 OSAHS patients in the Department of Otolaryngology,Head and Neck Surgery,Chaohu Hospital Affiliated to Anhui Medical University from January 2017 to December 2019,and set them as the case group.Use polysomnography(PSG)to record the patient's sleep related parameters,according to the sleep apnea hypopnea index(AHI),the cases were divided into three groups:mild,moderate,and severe,and another 50 healthy subjects in our hospital were selected as the control group.Compare the hematological indicators of each group[neutrophil count(NEUT),lymphocyte count(LY),platelet count(PLT),platelet distribution width(PDW),average platelet volume(MPV),neutrophil/lymphocyte ratio(NLR),platelet/lymphocyte ratio(PLR)],sleep apnea hypopnea index(AHI)and minimum blood oxygen saturation(LSaO_(2)).Results The differences of MPV,PDW,NLR,AHI,LSaO_(2) in each group were statistically significant(P<0.05).Among them,AHI,MPV,PDW,NLR:severe group>moderate group>mild group>control group;LSaO2:severe group<moderate group<mild group<control group;PLR comparison of each group,the difference was not statistically significant(P>0.05).Pearson correlation analysis showed that AHI was positively correlated with MPV,PDW and NLR(r=0.479,0.772,0.629,P<0.05).Conclusion MPV,PDW,and NLR are of great value in judging the severity of OSAHS patients.The detection of hematological indicators is economical,simple and feasible,and can be used for clinical preliminary assessment of the severity of OSAHS.

关 键 词：阻塞性睡眠呼吸暂停低通气综合征 血小板平均体积 血小板分布宽度 中性粒细胞/淋巴细胞比值 

分 类 号：R563.8[医药卫生—呼吸系统]