纳米级超声造影剂研究进展  

Research advancements of nanoscale ultrasound contrast agents

作　　者：张欣 红华[1] ZHANG Xin;HONG Hua(Department of Ultrasound, Inner Mongolia Autonomous Region People's Hospital, Hohhot 010017, China;Department of Medical Imaging and Nuclear Medicine, Inner Mongolia Medical University, Hohhot 010110, China)

机构地区：[1]内蒙古自治区人民医院超声科,内蒙古呼和浩特010017 [2]内蒙古医科大学影像医学与核医学系,内蒙古呼和浩特010110

出　　处：《中国介入影像与治疗学》2021年第2期118-121,共4页Chinese Journal of Interventional Imaging and Therapy

基　　金：内蒙古自治区科技计划项目(2019GG101)。

摘　　要：超声是疾病诊治最重要的手段之一,造影剂的应用显著增加了超声敏感性。纳米级造影剂不仅能从血管外溢出实现血管周围组织显像,且生物相容性、易修饰性及稳定性均比微米级造影剂更好。以生物标记物修饰纳米级造影剂表面,通过配体与受体的相互反应与目标组织特异性结合,可靶向释放负载药物或基因,促进分子成像水平诊断及治疗肿瘤、炎症等疾病。本文对纳米级超声造影剂研究进展进行综述。Ultrasound is one of the most important imaging methods for diagnosis and treatment of diseases.Ultrasonic contrast agent can greatly improve the sensitivity of ultrasound.Compared with micron-scale contrast agents,nanoscale contrast agents can not only overflow the vascular system and make the perivascular tissues visible,but also realize better biocompatibility,easier modification and higher stability.Modifying the surface of nanoscale contrast agents with biomarkers,specifically binding to target tissue through ligand-receptor interactions and releasing loaded drugs and genes to the target site on demand,nanoscale contrast agents may further improve diagnosis and treatment of tumors,inflammation and other diseases at the molecular imaging level.The research advancements of nanoscale ultrasound contrast agents were reviewed in this article.

关 键 词：超声检查 造影剂 纳米技术 分子显像 

分 类 号：R445.1[医药卫生—影像医学与核医学] R981[医药卫生—诊断学]