高渗氯化钠溶液治疗失血性休克的效果  

Effect of hypertonic sodium chloride solution in the treatment of hemorrhagic shock

作　　者：王晶 WANG Jing(Clinical Teaching Experimental Center,Shenyang Medical College,Liaoning Province,Shenyang 110000,China)

机构地区：[1]沈阳医学院临床教学实验中心,辽宁沈阳110000

出　　处：《中国当代医药》2021年第4期44-47,共4页China Modern Medicine

摘　　要：目的探讨高渗氯化钠溶液治疗失血性休克的效果。方法选取沈阳医学院2018年11月~2019年11月收治的82例失血性休克患者作为研究对象,按照随机数字表法分为对照组(41例)与观察组(41例)。对照组采用常规治疗,观察组在常规治疗的基础上联合高渗氯化钠溶液治疗。比较两组的输血量、输注总量、复苏时间、血红蛋白浓度、血压和心率、血清一氧化氮(NO)、整合素β_(2)-链(CD18)含量、并发症发生情况、死亡情况。结果观察组患者的输血量、输注总量少于对照组,复苏时间短于对照组,差异有统计学意义(P<0.05);观察组患者治疗后的血红蛋白浓度和血压水平均高于对照组,心率低于对照组,差异有统计学意义(P<0.05);观察组患者治疗后的血清NO及CD18含量低于对照组,差异有统计学意义(P<0.05);观察组患者的并发症总发生率以及死亡率低于对照组,差异有统计学意义(P<0.05)。结论在失血性休克患者治疗中应用高渗氯化钠溶液有助于减少输血量,缩短复苏时间,能提高血红蛋白浓度和血压水平,减少并发症的发生,有助于稳定生命体征和改善预后。Objective To investigate the effect of hypertonic sodium chloride solution in the treatment of hemorrhagic shock.Methods A total of 82 patients with hemorrhagic shock admitted to Shenyang Medical College from November 2018 to November 2019 were selected as the research objects.According to the random number table,they were divi-ded into the control group(41 cases)and the observation group(41 cases).The control group was treated with conventional treatment,the observation group was treated with hypertonic sodium chloride solution on the basis of conventional treatment.The blood transfusion volume,total transfusion volume,resuscitation time,hemoglobin concentration,blood pressure and heart rate,serum nitric oxide(NO),integrin β_(2)-chain(CD18)content,complications,and death were compared between the two groups.Results The blood transfusion and total infusion of the observation group were less than those of the control group,and the recovery time of the observation group was shorter than that of the control group,the differences were statistically significant(P<0.05).The hemoglobin concentration and blood pressure of the observation group after treatment were higher than those of the control group,the heart rate of the observation group after treatment was lower than that of the control group,the differences were statistically significant(P<0.05).The levels of serum NO and CD18 of the observation group after treatment were lower than those in the control group,the differences were statistically significant(P<0.05).The total incidence of complications and mortality in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion The application of hypertonic sodium chloride solution in the treatment of patients with hemorrhagic shock can help reduce blood transfusion,shorten recovery time,increase hemoglobin concentration and blood pressure,reduce complications,and help stabilize vital signs and improve prognosis.

关 键 词：失血性休克 高渗氯化钠溶液 复苏 血红蛋白 并发症 效果 

分 类 号：R459.7[医药卫生—急诊医学]