近10年中药治疗卵巢储备功能减退用药规律研究  

Study on Medication Laws of TCM for Treatment of Diminished Ovarian Reserve in Recent 10 Years

作　　者：张甜甜 李红杰 张文红 ZHANG Tiantian;LI Hongjie;ZHANG Wenhong(Shanxi University of Chinese Medicine,Taiyuan 030024,China;The Hospital of Shanxi University of Chinese Medicine,Taiyuan 030024,China)

机构地区：[1]山西中医药大学,山西太原030024 [2]山西中医药大学附属医院,山西太原030024

出　　处：《中国中医药信息杂志》2021年第2期35-38,共4页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：山西省卫生厅科技攻关项目(200701)。

摘　　要：目的分析中药治疗卵巢储备功能减退的用药配伍及组方规律。方法检索中国知识资源总库(CNKI)、中国学术期刊数据库(万方数据)、中文科技期刊数据库(维普网)2009年1月1日-2019年6月30日中医药(含中西医结合)治疗卵巢储备功能减退文献,提取文献中方剂及药物信息,统计药物使用及性味归经分布情况,对高频药物进行二项、三项关联分析及聚类分析。结果共纳入文献76篇,筛选方剂101首,涉及药物144味,药物类别16种,用药频次≥10的中药共36味,使用频次前3位分别为当归(79)、熟地黄(75)、菟丝子(72),药物类别频次前3位分别为补虚药(50)、活血化瘀药(20)、清热药(11),药性频次前3位分别为平(10)、温(10)、微温(6),药味频次前3位分别为甘(22)、苦(15)、辛(13),归经频次前3位分别为肝经(27)、肾经(20)、脾经(13)。用药频次≥10的36味药中二项关联18对,三项关联12组,聚为5类时聚类效果较好。结论卵巢储备功能减退的治疗药物以平甘温、归肝肾经者为多,治疗方法以调补肝肾、理气活血为主。Objective To summarize the compatibility and prescription laws of TCM for the treatment of diminished ovarian reserve. Methods Literature about TCM(including integrated traditional Chinese and Western medicine) for the treatment of diminished ovarian reserve was retrieved from Chinese National Knowledge Infrastructure(CNKI), Wanfang Database and VIP Journal Database from January 1, 2009 to June 30, 2019. Prescriptions and drug information were extracted, and medication, taste and property, and meridians were collected. Binomial and trinomial association analysis and cluster analysis were conducted for high-frequency drugs. Results Totally 76 articles were included and 101 prescriptions were screened, involving 144 kinds of Chinese materia medica and 16 categories. There were 36 kinds of Chinese materia medica with frequency ≥10, among which the top 3 were Angelica Sinensis(79), Rehmanniae Sinensis Radix(75) and Cuscuta Semen(72). The top three appeared frequently in drug categories were tonifying deficiency medicine(50), activating blood-circulation and dissipating blood-stasis medicine(20), and heat-clearing medicine(11), respectively. The top three of its drug properties were neutral(10), warm(10) and mildly warm(6);the top three drug tastes were sweet(22), bitterness(15) and pungent(13);the top three meridians were liver(27), kidney(20) and spleen(13) meridian, respectively. Among the 36 kinds of Chinese materia medica with medication frequency ≥10 times, there were 18 pairs of binomial associations, 12 groups of trinomial associations, and the clustering effect was good when the clustering was 5 types. Conclusion The medicine for diminished ovarian reserve is mainly neutral, sweet and warm, and the meridians are mainly liver and kidney. The therapeutic principles are mainly regulating and tonifying liver and kidney, regulating qi and activating blood circulation.

关 键 词：卵巢储备功能减退 中药 用药规律 数据挖掘 

分 类 号：R2-05[医药卫生—中医学] R271.917.5