中医调肝理脾法防治肝癌栓塞术后综合征的临床观察  

Effects of the traditional Chinese medicine Tiaogan Lipi granules on postembolization syndrome induced by transcatheter arterial chemoembolization for hepatocellular carcinoma

作　　者：杨海宁 樊庆胜[2] 刘福全 王华明 陈芋屹 杨国旺[2] Yang Haining;Fan Qingsheng;Liu Fuquan;Wang Huaming;Chen Yuyi;Yang Guowang(Department of Oncology,Shunyi Hospital,Beijing Traditional Chinese Medicine Hospital,Beijing 101300;Department of Oncology,Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University,Beijing 100010;Department of Interventional Therapy,Beijing Shijitan Hospital Affiliated to Capital Medical University,Beijing 100038;Department of Interventional Therapy,the Fifth Medical Center of PLA General Hospital,Beijing 100039,China)

机构地区：[1]北京中医医院顺义医院肿瘤科,北京101300 [2]首都医科大学附属北京中医医院肿瘤科,北京100010 [3]首都医科大学附属北京世纪坛医院介入治疗科,北京100038 [4]解放军总医院第五医学中心介入治疗科,北京100039

出　　处：《中华介入放射学电子杂志》2021年第1期20-24,共5页Chinese Journal of Interventional Radiology：electronic edition

基　　金：北京市科委首都市民健康项目培育—中医调肝理脾法防治原发性肝癌经动脉灌注化疗栓塞术后综合征的疗效评价(Z151100003915128)。

摘　　要：目的旨在观察和评估中医调肝理脾法在防治原发性肝癌栓塞术后综合征的疗效及安全性。方法本研究采用多中心、随机、双盲、安慰剂对照临床研究,将符合纳入标准的124例原发性肝癌患者随机分入治疗组(中药颗粒剂)和对照组(中药安慰剂)。在常规治疗基础上,治疗组患者口服中药颗粒剂(大柴胡汤合香砂六君子汤加减);对照组患者口服中药安慰剂,并在期间进行症状及相关实验室检查等疗效评价。结果两组基线(基本资料、术前症状指标)具有可比性(P>0.05)。中医症候学积分在术后7 d明显低于对照组(P<0.05),具有统计学意义;恶心、发热、腹痛等主要症状在术后7 d明显低于对照组(P<0.05),具有统计学意义。结论中医调肝理脾法中药能明显改善肝癌患者栓塞术后恶心、发热、腹痛等症状以及中医肝郁脾虚证型症候,安全性高,具有较好的临床疗效。Objective To evaluate the efficacy and safety of Tiaogan Lipi granules(TGLPG)on postembolization syndrome(PES)induced by transcatheter arterial chemoembolization(TACE)in patients with hepatocellular carcinoma(HCC).Methods This study was a multi-center,randomized,doubleblind,placebo-controlled trial.124 HCC patients were randomly divided into the experimental group and the placebo group at a 1:1 ratio.In the experimental group,the patients received TGLPG in addition to the standard treatment.And in the control group,the patients received the placebo.The PES was measured as the primary outcome,and traditional Chinese medicine(TCM)symptom scale and quality of life were measured as secondary outcomes.The hematological test,renal function,and electrocardiogram were used as the safety index in clinical trials.Results There was no significant difference between the two groups at baceline.At postoperative day 7,the TCM scale in the study group was significantly improved compared to that in the control group(P<0.05).The symptoms of PES,including nausea,fever,and pain,were found to be relieved significantly by TGLPG(P<0.05).Conclusions TGLPG may be an effective modality to relieve PES and improve the quality of life in patients with HCC after TACE.

关 键 词：原发性肝癌 栓塞术后综合征 中医 

分 类 号：R273[医药卫生—中西医结合]