1例D-二聚体远高于FDP原因分析  

A Causal Analysis of a Case:Why D-Dimer is Higher Than FDP

作　　者：李勤[1] 卢兴兵[1] 石佳[1] 陈娟[1] 周静[1] 曾素根[1] LI Qin;LU Xing-bin;SHI Jia;CHEN Juan;ZHOU Jing;ZENG Sugen(Department of Laboratory Medicine,West China Hospital,Sichuan University,Chengdu 610041,China)

机构地区：[1]四川大学华西医院实验医学科,四川成都610041

出　　处：《标记免疫分析与临床》2021年第1期179-180,共2页Labeled Immunoassays and Clinical Medicine

摘　　要：D-二聚体(D-dimer)水平的增高反映了体内血栓形成和纤溶活性增强,为临床继发性纤溶亢进的标志物。但在检测过程中受到一些因素的影响,从而造成D-二聚体假性增高,常见原因为类风湿因子(rheumatoid factor,RF)、异嗜性抗体等。现报道一例可能由大分子免疫球蛋白IgM影响,导致患者血浆中的D-二聚体检测结果远高于纤维蛋白(原)降解产物(fibrin/fibrinogen degradation product,FDP)结果。The increased level of D-dimer reflects thrombosis and enhanced fibrinolytic activity in vivo,which is a marker for the clinical secondary hyperfibrinolysis.However,during the detection process,it is affected by multiple factors,which can cause the pseudo-increased D-dimer.The common causes are rheumatoid factor(RF)and heterophilic antibodies,etc.This paper reports a case in which the detection result of D-dimer was much higher than fibrin/fibrinogen degradation product(FDP)due to the influence of macromolecule immunoglobulin IgM.

关 键 词：D-二聚体 纤维蛋白(原)降解产物 假性增高 类风湿因子 异嗜性抗体 IGM 

分 类 号：R446.1[医药卫生—诊断学]