青蒿中1个新的生物碱类化合物  

A new alkaloid from Artemisia annua

作　　者：李海波[1,2] 黄玉欣 秦大鹏 曹亮[2] 王振中[2] 姚新生[1] 于洋[1] LI Hai-bo;HUANG Yu-xin;QIN Da-peng;CAO Liang;WANG Zhen-zhong;YAO Xin-sheng;YU Yang(Institute of Traditional Chinese Medicine and Natural Products,Jinan University,Guangzhou 510632,China;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process,Kanion Pharmaceutical Co.,Ltd.,Lianyungang 222001,China;School of Pharmaceutical Sciences,Shenzhen University Health Science Center,Shenzhen 518060,China)

机构地区：[1]暨南大学中药及天然药物研究所,广东广州510632 [2]江苏康缘药业股份有限公司,中药制药过程新技术国家重点实验室,江苏连云港222001 [3]深圳大学医学部药学院,广东深圳518060

出　　处：《中草药》2021年第2期327-330,共4页Chinese Traditional and Herbal Drugs

基　　金：重大新药创制科技重大专项“十三五”计划(2018ZX09711001-008-005);国家自然科学基金重点项目(81630097)。

摘　　要：目的研究青蒿(黄花蒿Artemisia annua)干燥地上部分的化学成分。方法综合应用HP-20、硅胶、ODS、Sephadex LH-20和半制备液相等多种色谱学方法进行分离纯化,并根据化合物的理化性质和核磁共振波谱数据进行结构鉴定。结果从青蒿干燥地上部分水提取物中分离得到了5个化合物,分别鉴定为(S)-2,6,11-trimethyl-7,8-dihydro-6H-cyclohepta[b]pyridine-9-carboxylic acid(1)、arteannoide E(2)、蚱蜢酮(3)、(6S,9S)-长寿花糖苷(4)、artemanin B(5)。结论化合物1为新的生物碱,命名为青蒿生物碱;化合物3为首次从蒿属植物中分离得到。Objective To study the constituents from the dried aboveground part of Artemisia annua.Methods The compounds were isolated and purified by column chromatography of HP-20 macroporous resin,silica gel,ODS,Sephadex LH-20,and semi-preparative RP-HPLC.Their structures were elucidated by physicochemical properties and spectral analyses.Results Five compounds were isolated and identified from the water extract of A.annua,including alkaloid;(S)-2,6,11-trimethyl-7,8-dihydro-6H-cyclohepta[b]pyridine-9-carboxylic acid(1),arteannoide E(2),grasshopper ketone(3),(6S,9S)-roseoside(4)andartemanin B(5).Conclusion Compound 1 is a new alkaloid named arteannine.Compound 3 is identified from Artemisia genus for the first time.

关 键 词：青蒿 生物碱 (S)-2 6 11-trimethyl-7 8-dihydro-6H-cyclohepta[b]pyridine-9-carboxylic acid 青蒿生物碱 蚱蜢酮 (6S 9S)-长寿花糖苷 

分 类 号：R284.1[医药卫生—中药学]