广西壮族自治区人类免疫缺陷病毒阳性男男性接触人群乙型肝炎病毒感染现状及影响因素分析  

Analysis of current status and influencing factors of HBV infection among men who have sex with men with HIV-positive in Guangxi Zhuang Autonomous Region

作　　者：王建萍 董爽 姚添 鲁鸿雁 黄洪浪 冯永亮 李淑珍 王素萍 Wang Jianping;Dong Shuang;Yao Tian;Lu Hongyan;Huang Honglang;Feng Yongliang;Li Shuzhen;Wang Suping(Department of Epidemiology,Shanxi Medical University School of Public Health,Taiyuan 030001,China;不详)

机构地区：[1]山西医科大学公共卫生学院流行病学教研室,太原030001 [2]广西壮族自治区疾病预防控制中心艾滋病防治所 [3]广西壮族自治区崇左市宁明县疾病预防控制中心

出　　处：《中国药物与临床》2021年第4期549-553,共5页Chinese Remedies & Clinics

基　　金：国家科技重大专项(2018ZX10721202,2012ZXl0002001)。

摘　　要：目的了解广西壮族自治区人类免疫缺陷病毒(HIV)阳性男男性接触人群(MSM)乙型肝炎病毒(HBV)感染现状,并探讨HBV感染的影响因素。方法以2014年10月至2015年7月广西壮族自治区疾病预防控制中心艾滋病防制所和宁明县疾病预防控制中心管理的102例HIV阳性MSM为研究对象,进行面对面问卷调查,内容主要包括:一般人口学特征、HIV感染途径、吸毒史、性行为等。采集5 ml肘静脉血通过酶联免疫吸附试验(ELISA)法进行乙型肝炎表面抗原(HBsAg)定性检测。通过χ2检验、非条件Logistic回归探讨HIV阳性MSM人群HBV感染的影响因素。结果102例HIV阳性MSM中,HBV感染率为12.7%(13/102),既往乙肝疫苗接种率为44.1%(45/102),有HBV感染家族史者占26.5%(27/102)。多因素分析结果显示:既往接种乙肝疫苗[OR(95%CI):0.182(0.035,0.946)]是HIV阳性MSM发生HBV感染的保护因素。HBV感染家族史[OR(95%CI):5.757(1.553,21.344)]是HIV阳性MSM发生HBV感染的危险因素。结论广西地区HIV阳性MSM的HBV感染率高于当地一般人群,未接种乙肝疫苗和有HBV家族史者更容易感染HBV。Objective To investigate the current HBV infection and related influential factors among HIV-positive men who have sex with men(MSM)in Guangxi Zhuang Autonomous Region.Methods Included were 102 HIV-positive MSM registered to Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention(CDC)HIV Prevention Unit or Ningming County CDC between October 2014 and July 2015.A face-to-face questionnaire survey was conducted among these subjects to cover the general demographics,route of HIV infection,history of drug use,and sexual behaviors.Five ml of cubital venous blood were collected for qualitative detection of HBsAg by ELISA.Chi-square test and unconditional Logistic regression were used to determine the influential factors of HBV infection in HIV-positive MSM population.Results Among the 102 HIV-positive MSM,12.7%(13/102)were infected with HBV,44.1%(45/102)were previously vaccinated for hepatitis B,and 26.5%(27/102)had a family history of HBV infection.Multivariate analysis showed that previous vaccination for hepatitis B[OR(95%CI):0.182(0.035,0.946)]was a protective factor,while family history of HBV infection[OR(95%CI):5.757(1.553,21.344)]was a risk factor,for HBV infection among HIV-positive MSM.Conclusion The rate of HBV infection among HIV-positive MSM in Guangxi Zhuang Auto nomous Region is higher than that in the general population of the region.People unvaccinated for hepatitis B vaccine or with a family history of HBV are more likely to be infected with HBV.

关 键 词：男男性接触人群 人类免疫缺陷病毒 HBV感染 危险因素 

分 类 号：R512.62[医药卫生—内科学] R512.91[医药卫生—临床医学]