CYP17A1联合FGF5基因多态性与高血压的相关性评价  

Correlation evaluation between CYP17A1 combined with FGF5 gene polymorphism and hypertension

作　　者：刁晓艳 何燕[2] Diao Xiaoyan;He Yan(Department of Cardiology,Affiliated Hospital of Guizhou Medical University,Guiyang 550004,Guizhou,China.;Department of Molecular Biology,Guizhou Medical University,Guiyang 550004,Guizhou,China.)

机构地区：[1]贵州医科大学附属医院心血管科,贵州贵阳550004 [2]贵州医科大学分子生物学教研室,贵州贵阳550004

出　　处：《贵州医药》2021年第2期174-176,共3页Guizhou Medical Journal

基　　金：贵州省科技计划项目[黔科合LG字(2012)049];贵阳市科技项目[筑科合同(2019)9-1-15号]。

摘　　要：目的探讨CYP17A1基因C/T及FGF5 T/A多态性与原发性高血压(EH)关系。方法选取原发性高血压患者191例和健康体检者196例。应用TaqMan探针分析CYP17A1基因C/T和FGF5 T/A多态性的基因型,并探讨其相关性。结果经χ^(2)检验CYP17A1基因两组间基因型分布差异有统计学意义(χ^(2)=8.963,P<0.05),两组间等位基因频率分布差异有统计学意义(χ^(2)=9.913,P<0.05)。而FGF5 T/A多态性的基因型以及等位基因在两组中比较未见明显差异。多元回归分析中提示年龄、FGF5 TT基因型、CYP17A1 TT基因型和空腹血糖高于正常标准的人群具有更高的患病风险。空腹高血糖组较对照组患病风险提高4倍,且发现EH组血糖、甘油三酯、年龄及体重指数明显高于对照组。结论CYP17A1基因C/T基因多态性与原发性高血压发病可能相关,其中TT基因型及T等位基因的个体患高血压的风险升高。获得性因素对高血压的发病有明显的影响。Objective To investigate the relationship between CYP17A1 gene C/T and FGF5 T/A polymorphism and essential hypertension.Methods Total of 191 patients with essential hypertension and 196 healthy subjects were selected to analyze the genotypes of CYP17A1 gene C/T and FGF5 T/A polymorphisms by applying TaqMan probe,and to explore its correlation.Results Through chi-square test,in genotype distribution of CYP17A1 between the two groups that there were statistical significantly differences(χ^(2)=8.963,P<0.05),and in allele frequency distribution between the two groups there were statistical significantly differences(χ^(2)=9.913,P<0.05).The genotype and allele of FGF5 T/A polymorphism there were no statistical significantly differences between the two groups.Multivariate regression analysis suggested that age,FGF5 TT genotype,CYP17A1 TT genotype,and fasting glucose above normal levels were associated with higher risk.Compared with the control group,the risk of fasting blood glucose increased by 4 times,and blood glucose,triglyceride,age and body mass index in the hypertension group that there were significantly higher than those in the control group.Conclusion The C/T polymorphism of CYP17A1 gene may be related to the incidence of essential hypertension,in which individuals with TT genotype and T allele are at increased risk of hypertension.Acquired factors have obvious influence on the incidence of hypertension.

关 键 词：高血压 FGF5 CYP17A1 基因多态性 获得性因素 

分 类 号：R544.2[医药卫生—心血管疾病]